确定马里健康成年人血液学参数的参考范围。
Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults.
作者信息
Kone B, Maiga M, Baya B, Sarro Yds, Coulibaly N, Kone A, Diarra B, Sanogo M, Togo Acg, Goita D, Dembele M, Polis M A, Warfield J, Belson M, Dao S, Orsega S, Murphy R L, Diallo S, Siddiqui S
机构信息
University of Sciences, Techniques and Technologies of Bamako, Mali.
Leidos Biomedical Research, Inc., in support to NIAID, Bethesda, Maryland, USA.
出版信息
J Blood Lymph. 2017;7(1). doi: 10.4172/2165-7831.1000154. Epub 2017 Mar 15.
INTRODUCTION
Measurement of immuno-hematological parameters has been historically helpful in the diagnosis and treatment monitoring of many infectious diseases and cancers. However, these parameters have not yet been established in many developing countries where patient care strongly relies on such low-cost tests. This study describes the immuno-hematological parameter ranges for Malian healthy adults.
METHODS
A cross sectional study was conducted from August 2004 to May 2013. We included 213 healthy volunteers (173 male and 40 female), aged between 18-59 years. Median, 2.5 and 97.5 percentile ranges for each immuno-hematological parameter are presented.
RESULTS
In our study population, the hematological parameters' ranges were mostly different to the universal established ranges. We found in our population a Median white blood cell (WBC) count of 5200 cells/μL [3237.5-11900], Red Blood Cell (RBC) count of 4.94 10^6 [3.56-6.17], hemoglobin (Hb) of 14.2 g/dL [12.2-17.38], platelet count (Plt) of 275 10^3/μL [145.4-614.4], lymphocytes 2050/μL [1200-3800], neutrophils 2200/μL [1040-6220]; monocytes 200/μL [100-660]; eosinophils 131/μL [0-1026]; CD4 902 cells/μL [444-1669] and CD8 485 cells/μL [0-1272]. We found significant gender differences in RBC, Hb level and MPV. However, RBC and Hb were higher in males median values compared to females (median values) (p<0.001), whereas the Mean platelet volume lower values (MPV) in males than females (P<0.047). The hemoglobin level for some West African countries (Mali, Burkina Faso, Togo, and Nigeria) ranged from 13.5 to 15.1 g/dL for males and 12 to 13 g/dL for females. However in East and Southern Africa, the values were anywhere from 14.1 to 16.1 for males and 11.2 to 14.4 for females.
CONCLUSION
Our data may help physicians to better define hematological abnormalities in patients. They may also be used to define new "normal hematological values" in Malian population or in the whole West African population.
引言
免疫血液学参数的测量在许多传染病和癌症的诊断及治疗监测中一直发挥着重要作用。然而，在许多发展中国家，这些参数尚未确立，而这些国家的患者护理严重依赖此类低成本检测。本研究描述了马里健康成年人的免疫血液学参数范围。
方法
2004年8月至2013年5月进行了一项横断面研究。我们纳入了213名健康志愿者（173名男性和40名女性），年龄在18至59岁之间。给出了每个免疫血液学参数的中位数、第2.5百分位数和第97.5百分位数范围。
结果
在我们的研究人群中，血液学参数范围大多与普遍确立的范围不同。我们发现人群中白细胞（WBC）计数中位数为5200个/μL [3237.5 - 11900]，红细胞（RBC）计数为4.94×10^6 [3.56 - 6.17]，血红蛋白（Hb）为14.2 g/dL [12.2 - 17.38]，血小板计数（Plt）为275×10^3/μL [145.4 - 614.4]，淋巴细胞为2050/μL [1200 - 3800]，中性粒细胞为2200/μL [1040 - 6220]；单核细胞为200/μL [100 - 660]；嗜酸性粒细胞为131/μL [0 - 1026]；CD4为902个/μL [444 - 1669]，CD8为485个/μL [0 - 1272]。我们发现红细胞、血红蛋白水平和平均血小板体积存在显著性别差异。然而，男性红细胞和血红蛋白的中位数高于女性（中位数）（p<0.001），而男性平均血小板体积的较低值低于女性（P<0.047）。一些西非国家（马里、布基纳法索、多哥和尼日利亚）男性的血红蛋白水平在13.5至15.1 g/dL之间，女性在12至13 g/dL之间。然而在东非和南非，男性的值在14.1至16.1之间，女性在11.2至14.4之间。
结论
我们的数据可能有助于医生更好地界定患者的血液学异常。它们也可用于确定马里人群或整个西非人群的新“正常血液学值”。
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