Roman F, Soumireu-Mourat B
Laboratoire de Neurobiologie des Comportements, C.N.R.S. U.A. 372, Université de Provence, Marseille, France.
Brain Res. 1988 Mar 8;443(1-2):149-58. doi: 10.1016/0006-8993(88)91607-1.
BALB/c mice were bilaterally implanted with bipolar electrodes either in anterodorsal (ADH) or posteroventral hippocampus (PVH) in order to compare the effects of postsession electrical stimulation on memory processes. For each experiment, 30 s after the end of the first session, the animals were stimulated during 80 s. For both hippocampal regions, the stimulation intensity was half of the afterdischarge threshold value. Control groups were naive, ADH and PVH implanted non-stimulated animals. Different appetitive and aversive tasks were used. Subseizure stimulation never created a deficit. Depending on the region of the hippocampus stimulated and on the learning task, a retention enhancement was eventually observed. These data are in agreement with the involvement of hippocampus in initial stages of memory consolidation. Further, the subseizure stimulation permitted a functional dissociation between the two hippocampal regions. Both regions seemed involved in the integration of information, but the anterodorsal part would be rather related to behavioral inhibition, while the posteroventral part would have the capacity to induce an arousal state allowing behavioral flexibility.
为了比较会话后电刺激对记忆过程的影响，将BALB/c小鼠双侧植入双极电极，分别置于前背侧海马（ADH）或后腹侧海马（PVH）。在每个实验中，第一次会话结束后30秒，对动物进行80秒的刺激。对于两个海马区域，刺激强度均为后放电阈值的一半。对照组为未植入电极的正常小鼠、植入ADH电极但未刺激的小鼠以及植入PVH电极但未刺激的小鼠。使用了不同的奖赏性和厌恶性行为任务。阈下刺激从未造成记忆缺陷。根据受刺激的海马区域和学习任务的不同，最终观察到了记忆保持增强的现象。这些数据与海马在记忆巩固初始阶段的参与情况一致。此外，阈下刺激使得两个海马区域之间出现了功能分离。两个区域似乎都参与了信息整合，但前背侧部分与行为抑制关系更为密切，而后腹侧部分则有能力诱导一种唤醒状态，从而实现行为灵活性。
