OhioHealth, Physician Group-Neuroscience, Columbus, Ohio, USA.
Department of Psychology Saint Louis University, St. Louis, Missouri, USA.
Brain Inj. 2021 Apr 16;35(5):536-546. doi: 10.1080/02699052.2021.1887521. Epub 2021 Feb 17.
To examine associations between neuroimaging indicators of cerebral tract integrity and neurocognitive functioning in traumatic brain injury (TBI).
Between-Groups design with two TBI groups and controls.
Forty-four participants with TBI and 27 matched controls completed diffusion tensor imaging and neuropsychological measures of processing speed, attention, memory, and executive function. Multivariate analyses were conducted to examine group differences in white matter integrity (fractional anisotropy) for 11 regions of interest and cognitive performance among adult males with chronic phase, mild, moderate, or severe TBI. Correlational analyses investigated associations between white matter integrity, brain injury severity, and cognitive status.
Participants with moderate or severe TBI exhibited reduced white matter integrity in 8 of 11 ROIs and worse performance on most cognitive measures, relative to control participants. Persons with mild TBI did not differ from controls on white matter integrity values and differed on one measure of processing speed. Significant correlations were found between injury severity ratings and 10 ROIs, most notably between ROIs and measures of processing speed or memory.
These findings provide nuanced information regarding white matter connectivity as it relates to neurocognitive abilities across the TBI severity spectrum.
研究脑束完整性的神经影像学指标与创伤性脑损伤（TBI）神经认知功能之间的关系。
两组 TBI 患者和对照组的组间设计。
44 名 TBI 患者和 27 名匹配的对照组完成了弥散张量成像和认知处理速度、注意力、记忆和执行功能的神经心理学测量。对成年男性慢性期、轻度、中度或重度 TBI 的 11 个感兴趣区的白质完整性（各向异性分数）和认知表现进行了多变量分析。相关性分析研究了白质完整性、脑损伤严重程度和认知状态之间的关系。
与对照组相比，中度或重度 TBI 患者的 11 个感兴趣区中有 8 个区的白质完整性降低，大多数认知测试的表现也较差。轻度 TBI 患者的白质完整性值与对照组无差异，仅在一项处理速度测试中存在差异。损伤严重程度评分与 10 个感兴趣区之间存在显著相关性，最显著的是与处理速度或记忆测试相关的感兴趣区。
这些发现提供了有关创伤性脑损伤严重程度谱中与神经认知能力相关的白质连接的细致信息。
