Tissue Engineering and Cellular Therapy Group, Department of Physiotherapy, Medicine and Biological Sciences, University of A Coruña, A Coruña, Spain; Unidad de Medicina Regenerativa, Grupo de Investigación de Reumatología (GIR), Instituto de InvestigaciónBiomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), C/ As Xubias de Arriba 84, 15006, A Coruña, España; Centro de Investigaciones Científicas Avanzadas (CICA), As Carballeiras S/N, Campus de Elviña, 15071, A Coruña, España.
Department of Chemical Engineering, University of Vigo, Faculty of Sciences, Ourense, Spain; CINBIO, Universidade de Vigo, Departamento de Ingeniería Química, Campus Ourense, 32004 Ourense, Spain.
Carbohydr Polym. 2021 Apr 15;258:117692. doi: 10.1016/j.carbpol.2021.117692. Epub 2021 Jan 26.
Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules in OA treatment. However, the variability between fucoidans makes difficult the pursuit of the most suitable candidate to target specific pathological processes. By an in vitro experimental approach in chondrocytes and fibroblast-like synoviocytes, we observed that chemical composition of fucoidan, and specifically the phlorotannin content and the ratio sulfate:fucose, seems critically relevant for its biological activity. Nonetheless, other factors like concentration and molecular weight of the fucoidan may influence on its beneficial effects. Additionally, a cell-type dependent response was also detected. Thus, our results shed light on the potential use of fucoidans as natural molecules in the treatment of key pathological processes in the joint that favor the development of rheumatic disorders as OA.
骨关节炎（OA）是最常见的关节慢性疾病。尽管迄今为止，OA 还没有治愈方法。褐藻中的主要治疗成分之一褐藻糖胶，已成为 OA 治疗中很有前途的分子。然而，褐藻糖胶之间的可变性使得难以寻找最适合的候选物来针对特定的病理过程。通过软骨细胞和成纤维样滑膜细胞的体外实验方法，我们观察到褐藻糖胶的化学组成，特别是岩藻多酚的含量和硫酸根：岩藻糖的比例，对于其生物活性似乎至关重要。然而，褐藻糖胶的其他因素，如浓度和分子量，也可能影响其有益效果。此外，还检测到细胞类型依赖性反应。因此，我们的结果阐明了褐藻糖胶作为天然分子在治疗关节中关键病理过程中的潜在用途，这些过程有利于风湿性疾病的发展，如 OA。
