Nelson H S, Raine D, Doner H C, Posey W C
Am Rev Respir Dis. 1977 Nov;116(5):871-8. doi: 10.1164/arrd.1977.116.5.871.
Evidence of bronchodilator subsensitivity was sought in studies using the specific beta2 adrenergic agonist, albuterol. After a period of 1 or 2 weeks off all oral sympathomimetic agents, the mean response of the patients to the first dose of albuterol was consistently greater than the response after a period during which the drug had been administered regularly. Maximal decrease in response occurred after 2 weeks' of treatment, and there was no further decrease after prolonged treatment with the same dose of albuterol for periods as long as 1 year.
在使用特定的β2肾上腺素能激动剂沙丁胺醇的研究中探寻支气管扩张剂敏感性降低的证据。在停用所有口服拟交感神经药1或2周后，患者对第一剂沙丁胺醇的平均反应始终大于在定期给药一段时间后的反应。治疗2周后反应出现最大程度下降，并且在使用相同剂量的沙丁胺醇长期治疗长达1年的时间后，反应没有进一步下降。
