Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University Teaching Hospital, Marajgunj, Kathmandu, Nepal.
Kathmandu Univ Med J (KUMJ). 2020 Apr-Jun;18(70):207-209.
General paralysis of insane is a form of neurosyphilis which brings parenchymatous changes in the central nervous system. Its manifestations include a variety of neuropsychiatric symptoms ranging from cognitive impairment to overt psychosis. Clinicians face difficulties in proper diagnosis as variety of symptoms changes from one form to other within a short period of time. Rarity of the disease at this modern era of penicillin is also another factor in timely diagnosis and management of such cases. Here we present a case of general paralysis of insane who presented with variety of neuropsychiatric symptoms and have had great difficulties to reach into the diagnosis.
麻痹性痴呆是神经梅毒的一种形式，它会导致中枢神经系统实质发生变化。其表现包括从认知障碍到明显精神病等各种神经精神症状。由于各种症状在短时间内从一种形式转变为另一种形式，临床医生在正确诊断方面面临困难。在青霉素时代的今天，这种疾病的罕见性也是及时诊断和治疗此类病例的另一个因素。在这里，我们介绍了一例麻痹性痴呆患者，他表现出多种神经精神症状，并且很难做出诊断。
