Kramer G A, Kittleson M D, Fox P R, Lewis J, Pion P D
Department of Medicine, Animal Medical Center, New York, NY 10021, USA.
J Vet Intern Med. 1995 Jul-Aug;9(4):253-8. doi: 10.1111/j.1939-1676.1995.tb01076.x.
Plasma taurine concentrations were determined in 76 dogs with dilated cardiomyopathy (DCM), 28 dogs with acquired valvular disease (AVD), and 47 normal (control) dogs. The data were collected at 2 referral centers, The Animal Medical Center, New York, NY (AMC), and the University of California, Davis (UCD), and the studies were conducted independently. Different anticoagulants (sodium citrate at AMC and lithium heparin at UCD) were used to collect the plasma samples. Paired analysis of samples showed a significant difference in plasma taurine concentrations, depending on the anticoagulant used. Consequently, results from each clinic were analyzed separately. Plasma taurine concentrations were significantly higher in dogs with AVD (median, 133 nmol/mL; range, 25 to 229 nmol/mL) than in control dogs (median, 63 nmol/mL; range 44 to 224 nmol/mL) and dogs with DCM (median, 72 nmol/mL; range, 1 to 247 nmol/mL) at AMC (P < .001). The number of dogs with AVD at UCD was too small to draw meaningful conclusions. At UCD, the median plasma taurine concentration was 98 nmol/mL (range, 28-169 nmol/mL) in dogs with AVD, 75 nmol/mL (range, 0.1-184 nmol/mL) in dogs with DCM, and 88 nmol/mL (range 52-180 nmol/mL) in control dogs. There were no significant differences in plasma taurine concentrations between dogs with DCM and the control dogs at either hospital. Congestive heart failure and administration of cardiac medication had no significant effect on plasma taurine concentrations. Plasma taurine concentration was low (< 25 nmol/mL) in 17% (13/76) of the dogs with DCM. Seven of the 13 dogs with low plasma taurine concentrations were Cocker Spaniels or Golden Retrievers.(ABSTRACT TRUNCATED AT 250 WORDS)
对76只患有扩张型心肌病（DCM）的犬、28只患有后天性瓣膜病（AVD）的犬以及47只正常（对照）犬测定了血浆牛磺酸浓度。数据收集于两个转诊中心，即纽约州纽约市的动物医疗中心（AMC）和加利福尼亚大学戴维斯分校（UCD），且研究独立进行。使用了不同的抗凝剂（AMC使用柠檬酸钠，UCD使用肝素锂）来采集血浆样本。对样本的配对分析显示，根据所使用的抗凝剂不同，血浆牛磺酸浓度存在显著差异。因此，对每个诊所的结果分别进行了分析。在AMC，患有AVD的犬血浆牛磺酸浓度（中位数为133 nmol/mL；范围为25至229 nmol/mL）显著高于对照犬（中位数为63 nmol/mL；范围为44至224 nmol/mL）和患有DCM的犬（中位数为72 nmol/mL；范围为1至247 nmol/mL）（P <.001）。UCD患有AVD的犬数量过少，无法得出有意义的结论。在UCD，患有AVD的犬血浆牛磺酸浓度中位数为98 nmol/mL（范围为28 - 169 nmol/mL），患有DCM的犬为75 nmol/mL（范围为0.1 - 184 nmol/mL），对照犬为88 nmol/mL（范围为52 - 180 nmol/mL）。在两家医院中，患有DCM的犬与对照犬的血浆牛磺酸浓度均无显著差异。充血性心力衰竭和心脏药物的使用对血浆牛磺酸浓度无显著影响。17%（13/76）患有DCM的犬血浆牛磺酸浓度较低（< 25 nmol/mL）。血浆牛磺酸浓度低的13只犬中有7只为可卡犬或金毛寻回犬。（摘要截短于250字）
