Liu Junjun, Yang Lin, Qin Ping, Zhang Shiqing, Yung Ken Kin Lam, Huang Zhifeng
Department of Physics, Hong Kong Baptist University (HKBU), Kowloon Tong, Kowloon, Hong Kong SAR, China.
HKBU Institute of Research and Continuing Education, Shenzhen, Guangdong, 518057, China.
Adv Mater. 2021 Dec;33(50):e2005506. doi: 10.1002/adma.202005506. Epub 2021 Feb 17.
Inorganic nanoparticles offer a multifunctional platform for biomedical applications in drug delivery, biosensing, bioimaging, disease diagnosis, screening, and therapies. Homochirality prevalently exists in biological systems composed of asymmetric biochemical activities and processes, so biomedical applications essentially favor the usage of inorganic chiral nanomaterials, which have been widely studied in the past two decades. Here, the latest investigations are summarized including the characterization of 3D stereochirality, the bionic fabrication of hierarchical chirality, extension of the compositional space to poly-elements, studying optical activities with the (sub-)single-particle resolution, and the experimental demonstration in biomedical applications. These advanced studies pave the way toward fully understanding the two important chiral effects (i.e., the chiroptical and enantioselective effects), and prospectively promote the flexible design and fabrication of inorganic chiral nanoparticles with engineerable functionalities to solve diverse practical problems closely associated with environment and public health.
无机纳米粒子为药物递送、生物传感、生物成像、疾病诊断、筛查及治疗等生物医学应用提供了一个多功能平台。同手性普遍存在于由不对称生化活性和过程组成的生物系统中，因此生物医学应用本质上倾向于使用无机手性纳米材料，在过去二十年中，这类材料已得到广泛研究。在此，总结了最新的研究进展，包括三维立体手性的表征、分级手性的仿生制造、组成空间向多元素的扩展、以（亚）单粒子分辨率研究光学活性以及生物医学应用中的实验演示。这些前沿研究为全面理解两种重要的手性效应（即手性光学效应和对映选择性效应）铺平了道路，并有望促进具有可设计功能的无机手性纳米粒子的灵活设计与制造，以解决与环境和公众健康密切相关的各种实际问题。
