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新冠病毒患者嗅觉和味觉障碍的流行情况:社区护理机构研究。

Prevalence of olfactory and taste dysfunction in COVID-19 patients: a community care facility study.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Singapore General Hospital, Singapore, Singapore.

Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore, Singapore.

出版信息

Eur Arch Otorhinolaryngol. 2021 Sep;278(9):3375-3380. doi: 10.1007/s00405-021-06647-2. Epub 2021 Feb 17.

Abstract

PURPOSE

We aim to study the prevalence of olfactory and taste dysfunction (OTD) in subjects residing in a Community Care Facility (CCF), a center unique to Singapore that is dedicated to isolate foreign workers with COVID-19 infection who have mild disease with minimal or no symptoms.

METHODS

This is a cross-sectional study analyzing data prospectively collected from COVID-19-positive subjects who were admitted into a single-center Singapore EXPO CCF from 1st May 2020 to 1st July 2020. The following variables were collected: age, gender, ethnicity, anosmia, ageusia and acute respiratory infection (ARI) symptoms. Symptoms of anosmia and ageusia were self-declared via a mandatory questionnaire administered on admission.

RESULTS

A total of 1983 subjects were included. The overall prevalence of anosmia and ageusia is 3.0% and 2.6%, respectively. 58% of anosmic subjects have co-existent ageusia and 72.6% of anosmic subjects have no concurrent sinonasal symptoms. OTD is less likely to present in subjects who are asymptomatic for ARI, compared to those symptomatic for ARI (anosmia: 2.0% versus 4.4% p = 0.002; ageusia: 1.6% versus 4.2% p < 0.001). There is a difference in the prevalence of OTD between the different ethnic groups (Indian, Chinese, Bangladeshi and Others), with Chinese and Bangladeshi reporting a higher prevalence (p < 0.043) CONCLUSION: The true prevalence of OTD in COVID-19-positive subjects may be low with aggressive screening of all subjects, including those asymptomatic for ARI.

摘要

目的

我们旨在研究居住在社区护理设施(CCF)中的受试者嗅觉和味觉功能障碍(OTD)的患病率,CCF 是新加坡特有的一个中心,致力于隔离 COVID-19 感染的外籍工人,这些工人患有轻度疾病,症状轻微或没有症状。

方法

这是一项横断面研究,分析了 2020 年 5 月 1 日至 2020 年 7 月 1 日期间从新加坡博览中心单一中心 CCF 收治的 COVID-19 阳性患者前瞻性收集的数据。收集了以下变量:年龄、性别、种族、嗅觉丧失、味觉丧失和急性呼吸道感染(ARI)症状。嗅觉丧失和味觉丧失的症状通过入院时强制问卷调查自行申报。

结果

共纳入 1983 例患者。嗅觉丧失和味觉丧失的总患病率分别为 3.0%和 2.6%。58%的嗅觉丧失患者同时存在味觉丧失,72.6%的嗅觉丧失患者无同期鼻窦症状。与 ARI 症状患者相比,无 ARI 症状患者 OTD 发生的可能性较低(嗅觉丧失:2.0%对 4.4%,p=0.002;味觉丧失:1.6%对 4.2%,p<0.001)。不同种族(印度人、中国人、孟加拉人和其他人)之间 OTD 的患病率存在差异,中国人和孟加拉人报告的患病率较高(p<0.043)。

结论

对所有患者(包括无症状 ARI 患者)进行积极筛查,可能会降低 COVID-19 阳性患者 OTD 的真实患病率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9458/7886642/c85e4f6a4a35/405_2021_6647_Fig1_HTML.jpg

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