Ranamalla Saketh Reddy, Porfire Alina Silvia, Tomuță Ioan, Banciu Manuela
Department of Pharmaceutical Technology and Bio Pharmacy, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania.
Doctoral School in Integrative Biology, Faculty of Biology and Geology, "Babeș-Bolyai" University, 400015 Cluj-Napoca, Romania.
Pharmaceutics. 2022 Aug 18;14(8):1733. doi: 10.3390/pharmaceutics14081733.
Tissue regeneration is a prominent area of research, developing biomaterials aimed to be tunable, mechanistic scaffolds that mimic the physiological environment of the tissue. These biomaterials are projected to effectively possess similar chemical and biological properties, while at the same time are required to be safely and quickly degradable in the body once the desired restoration is achieved. Supramolecular systems composed of reversible, non-covalently connected, self-assembly units that respond to biological stimuli and signal cells have efficiently been developed as preferred biomaterials. Their biocompatibility and the ability to engineer the functionality have led to promising results in regenerative therapy. This review was intended to illuminate those who wish to envisage the niche translational research in regenerative therapy by summarizing the various explored types, chemistry, mechanisms, stimuli receptivity, and other advancements of supramolecular systems.
组织再生是一个重要的研究领域，旨在开发可调节的、具有机械性能的支架类生物材料，以模拟组织的生理环境。这些生物材料预计能有效具备相似的化学和生物学特性，同时一旦实现预期的修复，还需要在体内安全且快速地降解。由可逆的、非共价连接的自组装单元组成的超分子系统，能够响应生物刺激并向细胞发出信号，已被有效地开发为首选生物材料。它们的生物相容性和功能设计能力在再生治疗中取得了令人期待的成果。本综述旨在通过总结超分子系统的各种探索类型、化学性质、作用机制、刺激感受性及其他进展，为那些希望展望再生治疗中细分转化研究的人提供启示。
