静电纺丝淀粉纳米纤维：在潜在药物应用方面的最新进展、挑战和策略。
Electrospun starch nanofibers: Recent advances, challenges, and strategies for potential pharmaceutical applications.
机构信息
The State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China.
The State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China.
出版信息
J Control Release. 2017 Apr 28;252:95-107. doi: 10.1016/j.jconrel.2017.03.016. Epub 2017 Mar 9.
Electrospun starch nanofibers have high porosity, extremely high specific surface area, and biocompatible, biodegradable, and bioabsorbable properties. As a result, starch nanofibers have great potential in pharmaceutical applications, including drug delivery, wound dressing, and tissue engineering. Here, we summarize and review the recent developments in the synthesis of electrospun starch fibers from common starch, modified starch, and hybrids with other polymers. Moreover, the challenges and strategies for the fabrication and application of starch fibers in pharmaceutical applications are presented.
静电纺丝淀粉纳米纤维具有高孔隙率、极高的比表面积以及生物相容性、可生物降解性和生物可吸收性。因此，淀粉纳米纤维在药物输送、伤口敷料和组织工程等药物应用方面具有巨大的潜力。在这里，我们总结和回顾了近年来通过普通淀粉、改性淀粉以及与其他聚合物的混合物来合成静电纺丝淀粉纤维的最新进展。此外，还介绍了在药物应用中制备和应用淀粉纤维所面临的挑战和策略。
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