Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Signal Transduct Target Ther. 2021 Feb 18;6(1):68. doi: 10.1038/s41392-020-00444-9.
In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for anticancer treatments. Protein translation is affected by many factors including translation initiation factors and RNA-binding proteins. Recently, modifications of mRNAs mainly N6-methyladenine (mA) modification and noncoding RNAs, such as microRNAs and long noncoding RNAs are involved. In this review, we generally summarized the recent advances on the regulation of protein translation by the interplay between mRNA modifications and ncRNAs. By doing so, we hope this review could offer some hints for the development of novel approaches in precision therapy of human cancers.
除了基因转录和翻译后蛋白质修饰的失调外，mRNA 到蛋白质的翻译异常在各种癌症的发病机制中也起着重要作用。针对 mRNA 翻译有望成为癌症治疗的潜在方法。蛋白质翻译受到许多因素的影响，包括翻译起始因子和 RNA 结合蛋白。最近，mRNA 的修饰主要是 N6-甲基腺嘌呤（mA）修饰和非编码 RNA，如 microRNAs 和长非编码 RNA 参与其中。在这篇综述中，我们总结了 mRNA 修饰和 ncRNA 之间相互作用对蛋白质翻译调控的最新进展。希望这篇综述能为人类癌症精准治疗新方法的发展提供一些启示。
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