Zhong Shan, He Songzhe
Department of Acupuncture, Guilin Hospital of Traditional Chinese Medicine, Guilin, China.
Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, China.
Front Microbiol. 2021 Feb 1;12:558003. doi: 10.3389/fmicb.2021.558003. eCollection 2021.
is a Gram-negative opportunistic nosocomial pathogen, which can cause ventilator-related and blood infection in critically ill patients. The resistance of clinical isolates to common antimicrobials and their tolerance to desiccation have emerged as a serious problem to public health. In the process of pathogenesis, bacteria release signals, which regulate virulence and pathogenicity-related genes. Such bacteria coordinate their virulent behavior in a cell density-dependent phenomenon called quorum sensing (QS). In contrast, the two main approaches of QS interference, quorum sensing inhibitors (QSIs) and quorum quenching (QQ) enzymes, have been developed to reduce the virulence of bacteria, thus reducing the pressure to produce bacterial drug resistance. Therefore, QSIs or QQ enzymes, which interfere with these processes, might potentially inhibit bacterial QS and ultimately biofilm formation. In this review, we aim to describe the state-of-art in the QS process in and elaborate on the use of QSIs or QQ enzymes as antimicrobial drugs in various potential sites of the QS pathway.
是一种革兰氏阴性机会性医院病原体，可导致重症患者发生呼吸机相关性感染和血液感染。临床分离株对常见抗菌药物的耐药性及其对干燥的耐受性已成为公共卫生的一个严重问题。在发病过程中，细菌释放信号，这些信号调节毒力和致病性相关基因。这类细菌在一种称为群体感应（QS）的细胞密度依赖性现象中协调其毒力行为。相比之下，已开发出群体感应干扰的两种主要方法，即群体感应抑制剂（QSIs）和群体淬灭（QQ）酶，以降低细菌的毒力，从而减轻产生细菌耐药性的压力。因此，干扰这些过程的QSIs或QQ酶可能会抑制细菌的群体感应并最终抑制生物膜形成。在本综述中，我们旨在描述该菌群体感应过程的最新进展，并详细阐述QSIs或QQ酶作为抗菌药物在群体感应途径的各个潜在位点的应用。
