Khalif Omar I, Alkalifawi Esam J
Department of Biology, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, IRQ.
Cureus. 2025 May 5;17(5):e83506. doi: 10.7759/cureus.83506. eCollection 2025 May.
(is an opportunistic pathogen responsible for severe nosocomial infections, often exhibiting multidrug resistance (MDR), which limits treatment options. As a promising alternative to conventional antibiotics, zinc oxide nanoparticles (ZnO NPs) have attracted significant attention due to their potent antimicrobial properties. In particular, plant-based biosynthesis of ZnO NPs offers an eco-friendly, cost-effective, and sustainable approach compared to chemical and physical synthesis methods. Phytochemicals reduce and stabilize agents in the synthesis of NPs, enhancing biocompatibility and minimizing toxic effects. This review explores the potential of biosynthesized ZnO NPs for controlling infections and highlighting their antimicrobial mechanisms. Furthermore, we discuss the advantages of plant-mediated synthesis and the challenges in clinical translation. Understanding the role of biosynthesized ZnO NPs in combating MDR pathogens could pave the way for novel therapeutic strategies against infections.
（是一种机会致病菌，可导致严重的医院感染，常表现出多重耐药性（MDR），这限制了治疗选择。作为传统抗生素的一种有前景的替代品，氧化锌纳米颗粒（ZnO NPs）因其强大的抗菌性能而备受关注。特别是，与化学和物理合成方法相比，基于植物的ZnO NPs生物合成提供了一种环保、经济高效且可持续的方法。植物化学物质在NPs合成中起到还原剂和稳定剂的作用，增强了生物相容性并将毒性作用降至最低。本综述探讨了生物合成的ZnO NPs在控制感染方面的潜力，并突出了它们的抗菌机制。此外，我们讨论了植物介导合成的优势以及临床转化中的挑战。了解生物合成的ZnO NPs在对抗多重耐药病原体中的作用，可能为针对感染的新型治疗策略铺平道路。 ）
需注意，原文中“ infections”表述不完整，翻译时保留了原文状态。
