Green-Synthesized Zinc Oxide Nanoparticles for Acinetobacter baumannii Control: A Review of Plant-Based Approaches.

(is an opportunistic pathogen responsible for severe nosocomial infections, often exhibiting multidrug resistance (MDR), which limits treatment options. As a promising alternative to conventional antibiotics, zinc oxide nanoparticles (ZnO NPs) have attracted significant attention due to their potent antimicrobial properties. In particular, plant-based biosynthesis of ZnO NPs offers an eco-friendly, cost-effective, and sustainable approach compared to chemical and physical synthesis methods. Phytochemicals reduce and stabilize agents in the synthesis of NPs, enhancing biocompatibility and minimizing toxic effects. This review explores the potential of biosynthesized ZnO NPs for controlling infections and highlighting their antimicrobial mechanisms. Furthermore, we discuss the advantages of plant-mediated synthesis and the challenges in clinical translation. Understanding the role of biosynthesized ZnO NPs in combating MDR pathogens could pave the way for novel therapeutic strategies against infections.