Khan Rabiya Tabbassum, Sharma Vanshika, Khan Sofia Sharief, Rasool Shafaq
Molecular Biology Lab, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India.
Front Microbiol. 2024 Oct 3;15:1455759. doi: 10.3389/fmicb.2024.1455759. eCollection 2024.
The increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. The looming threat of the return of the pre-antibiotic era has caused a sense of urgency to protect and conserve the potency of antibiotic therapy. One of the perverse effects of antibiotic resistance is the dissemination of its causative agents from non-clinically important strains to clinically important strains and vice versa. The popular saying "Prevention is better than cure" is appropriate for tackling antibiotic resistance. On the one hand, new and effective antibiotics are required; on the other hand, better measures for the use of antibiotics, along with increased awareness in the general public related to antibiotic use, are essential. Awareness, especially of appropriate antibiotic use, antibiotic resistance, its dissemination, and potential threats, can help greatly in controlling the use and abuse of antibiotics, and the containment of antibiotic resistance. Antibiotic drugs' effectiveness can be enhanced by producing novel antibiotic analogs or adding adjuvants to current antibiotics. Combinatorial therapy of antibiotics has proven successful in treating multidrug-resistant (MDR) bacterial infections. This review aims to highlight the current global situation of antibiotic resistance and discuss the methods used to monitor, prevent, inhibit, or reverse bacterial resistance mechanisms in the fight against antibiotic resistance.
抗生素耐药性威胁的不断增加以及感染治疗选择的日益减少，使人类陷入了困境。抗生素前时代回归的潜在威胁引发了保护和保存抗生素治疗效力的紧迫感。抗生素耐药性的一个不良影响是其病原体从非临床重要菌株传播到临床重要菌株，反之亦然。“预防胜于治疗”这句俗语适用于应对抗生素耐药性问题。一方面，需要新型有效的抗生素；另一方面，更好的抗生素使用措施以及提高公众对抗生素使用的认识至关重要。提高认识，特别是对抗生素的合理使用、抗生素耐药性、其传播以及潜在威胁的认识，有助于极大地控制抗生素的使用和滥用，并遏制抗生素耐药性。通过生产新型抗生素类似物或在现有抗生素中添加佐剂，可以提高抗生素药物的有效性。抗生素联合疗法已被证明在治疗多重耐药（MDR）细菌感染方面是成功的。本综述旨在突出当前抗生素耐药性的全球形势，并讨论在抗击抗生素耐药性过程中用于监测、预防、抑制或逆转细菌耐药机制的方法。
