Khosravi Alireza, Rajabi Hamid Reza, Vakhshoori Mehrbod, Rabiei Katayoun, Hosseini Seyed Mohsen, Mansouri Asieh, Roghani-Dehkordi Farshad, Najafian Jamshid, Rahimi Mojtaba, Jafari-Koshki Tohid, Sadeghian Babak, Shishehforoush Mansour, Lahijanzadeh Ahmadreza, Taheri Marzieh, Sarrafzadegan Nizal
Professor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2020 Jul;16(4):178-184. doi: 10.22122/arya.v16i4.2032.
The relation between air pollution and cardiovascular diseases (CVDs) risk factors, especially blood pressure (BP) levels, has been less frequently assessed. The aim of this study was evaluating the association between air pollutants of less than 2.5 µm [particulate matter (PM2.5)] and BP indices among individuals admitted with CVDs and pulmonary diseases.
This cross-sectional study was in context of air pollution associated with hospitalization and mortality of CVDs and respiratory diseases (CAPACITY) study. Data of 792 Iranian patients referring to two hospitals in Isfahan, Iran, for cardiovascular or respiratory problems from March 2011 to March 2012 were used for analysis. BP indices including systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) were obtained from patients' medical forms and mean PM2.5 concentrations during 24 hours prior to admission of each patient were obtained from Isfahan Department of Environment (DOE).
Mean ± standard deviation (SD) of participants' age were 62.5 ± 15.9 years. All BP indices on admission were significantly higher in women compared with men. Adjustment of all potential confounders including age, sex, temperature, wind speed, and dew point revealed that increasing one quartile in PM2.5 concentrations had been associated with 1.98 mmHg raising in SBP at the time of admission [95% confidence interval (CI) = 0.41-3.54, P = 0.010]. Women with cardiac diseases had higher all BP indices with increased PM2.5 concentration [SBP: β: 4.30, 95% CI = 0.90-7.70, P = 0.010; DBP: β: 1.89, 95% CI = 0.09-3.69, P = 0.040; MAP: β: 3.09, 95% CI = 0.68-5.51, P= 0.010, respectively).
Our findings suggest that increasing PM2.5 concentration has been positively associated with raising SBP in total population and all BP indices among women with cardiac problems at admission time. Several comprehensive studies are required for confirming these relations.
空气污染与心血管疾病（CVDs）风险因素，尤其是血压（BP）水平之间的关系较少被评估。本研究的目的是评估小于2.5微米的空气污染物[细颗粒物（PM2.5）]与因心血管疾病和肺部疾病入院的个体的血压指标之间的关联。
这项横断面研究是在空气污染与心血管疾病和呼吸系统疾病的住院及死亡率相关研究（CAPACITY）的背景下进行的。使用了2011年3月至2012年3月期间转诊至伊朗伊斯法罕两家医院治疗心血管或呼吸系统问题的792名伊朗患者的数据进行分析。血压指标包括收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP），这些数据从患者的病历中获取，每位患者入院前24小时内的平均PM2.5浓度从伊斯法罕环境部（DOE）获取。
参与者的平均年龄±标准差（SD）为62.5±15.9岁。入院时所有血压指标女性均显著高于男性。对包括年龄、性别、温度、风速和露点在内的所有潜在混杂因素进行调整后发现，PM2.5浓度每增加一个四分位数，入院时收缩压升高1.98 mmHg [95%置信区间（CI）=0.41 - 3.54，P = 0.010]。患有心脏病的女性，随着PM2.5浓度升高所有血压指标均更高[SBP：β：4.30，95%CI = 0.90 - 7.70，P = 0.010；DBP：β：1.89，95%CI = 0.09 - 3.69，P = 0.040；MAP：β：3.09，95%CI = 0.68 - 5.51，P = 0.01分别）。
我们的研究结果表明，PM2.5浓度升高与总体人群收缩压升高以及入院时患有心脏病的女性的所有血压指标升高呈正相关。需要进行多项综合研究来证实这些关系。
