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一名原发性抗体缺陷儿童的新型冠状病毒肺炎

COVID-19 in a child with primary antibody deficiency.

作者信息

Ahanchian Hamid, Moazzen Nasrin, Sezavar Majid, Khalighi Negar, Khoshkhui Maryam, Aelami Mohammad Hassan, Motevalli Haghi Nasrin Sadat, Rezaei Nima

机构信息

Allergy Research Center Mashhad University of Medical Sciences Mashhad Iran.

Clinical Research Development Unit of Akbar hospital Mashhad University of medical Sciences Mashhad Iran.

出版信息

Clin Case Rep. 2020 Dec 8;9(2):755-758. doi: 10.1002/ccr3.3643. eCollection 2021 Feb.

DOI:10.1002/ccr3.3643
PMID:33598240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7869323/
Abstract

Although presentation of COVID-19 in patients with immunodeficiency could be mild, it should not be missed, while early diagnosis and appropriate treatment can survive infected patients. Because even severe infections in PID patients may be presented with few symptoms and signs, this diagnosis should be considered in those immunocompromised patients who have exacerbating preexisting symptoms.

摘要

尽管免疫缺陷患者感染新型冠状病毒肺炎(COVID-19)的症状可能较轻,但仍不应漏诊,早期诊断和适当治疗可使感染患者存活。由于原发性免疫缺陷(PID)患者即使发生严重感染,症状和体征也可能较少,因此对于那些原有症状加重的免疫功能低下患者,应考虑这一诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb1/7869323/cf42c8840298/CCR3-9-755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb1/7869323/9a0e29fdd430/CCR3-9-755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb1/7869323/cf42c8840298/CCR3-9-755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb1/7869323/9a0e29fdd430/CCR3-9-755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb1/7869323/cf42c8840298/CCR3-9-755-g002.jpg

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2
Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.先天性免疫缺陷患者的 2019 年冠状病毒病:一项国际研究。
J Allergy Clin Immunol. 2021 Feb;147(2):520-531. doi: 10.1016/j.jaci.2020.09.010. Epub 2020 Sep 24.
3
COVID-19: Transmission, prevention, and potential therapeutic opportunities.
Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review.
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Allergy Asthma Clin Immunol. 2023 Aug 9;19(1):69. doi: 10.1186/s13223-023-00831-1.
4
COVID-19-related health outcomes in people with primary immunodeficiency: A systematic review.原发性免疫缺陷患者的 COVID-19 相关健康结局:系统评价。
Clin Immunol. 2022 Oct;243:109097. doi: 10.1016/j.clim.2022.109097. Epub 2022 Aug 13.
5
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J Clin Immunol. 2018 Oct;38(7):816-832. doi: 10.1007/s10875-018-0556-1. Epub 2018 Oct 9.