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三阴性乳腺癌专家见解:为下一波治疗做准备

Expert Insights on Triple-Negative Breast Cancer: Preparing for the Next Wave of Treatments.

作者信息

Greene Heather R, Schwartzberg Lee S

机构信息

West Cancer Center & Research Institute, Memphis, Tennessee.

出版信息

J Adv Pract Oncol. 2020 Apr;11(3):266-270. doi: 10.6004/jadpro.2020.11.3.10. Epub 2020 Apr 1.

DOI:10.6004/jadpro.2020.11.3.10
PMID:33598323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7857324/
Abstract

Heather R. Greene, MSN, FNP, AOCNP®, and Lee S. Schwartzberg, MD, FACP, discussed the current and future treatment landscape for triple-negative breast cancer, including recent and emerging data on approved treatments, novel therapeutic options being investigated, and best practices for identifying and monitoring adverse events associated with PARP and immune checkpoint inhibitors at JADPRO Live 2019.

摘要

希瑟·R·格林(Heather R. Greene),护理学硕士、家庭执业护士、高级肿瘤临床执业护士(AOCNP®),以及李·S·施瓦茨伯格(Lee S. Schwartzberg),医学博士、美国内科医师学会会员(FACP),在2019年JADPRO直播活动中讨论了三阴性乳腺癌的当前及未来治疗前景,包括已批准治疗方法的最新及新出现的数据、正在研究的新型治疗选择,以及识别和监测与PARP和免疫检查点抑制剂相关不良事件的最佳实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21ec/7857324/ff69947dc214/jadpro-11-266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21ec/7857324/ff69947dc214/jadpro-11-266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21ec/7857324/ff69947dc214/jadpro-11-266-g001.jpg

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本文引用的文献

1
Olaparib: A Novel Therapy for Metastatic Breast Cancer in Patients With a 1/2 Mutation.奥拉帕尼:一种用于治疗携带1/2突变的转移性乳腺癌患者的新型疗法。
J Adv Pract Oncol. 2019 Mar;10(2):167-174. Epub 2019 Mar 1.
2
Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.Sacituzumab Govitecan-hziy 治疗难治性转移性三阴性乳腺癌。
N Engl J Med. 2019 Feb 21;380(8):741-751. doi: 10.1056/NEJMoa1814213.
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Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation.他拉唑帕尼治疗携带有胚系 BRCA 突变的晚期乳腺癌患者。
N Engl J Med. 2018 Aug 23;379(8):753-763. doi: 10.1056/NEJMoa1802905. Epub 2018 Aug 15.
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Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.BRCA1/2 突变型和三阴性乳腺癌 BRCA 样亚组中的卡铂:TNT 试验。
Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. Epub 2018 Apr 30.
5
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.免疫检查点抑制剂治疗患者免疫相关不良反应的管理:美国临床肿瘤学会临床实践指南。
J Clin Oncol. 2018 Jun 10;36(17):1714-1768. doi: 10.1200/JCO.2017.77.6385. Epub 2018 Feb 14.
6
Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer.恩杂鲁胺治疗雄激素受体表达的三阴性乳腺癌。
J Clin Oncol. 2018 Mar 20;36(9):884-890. doi: 10.1200/JCO.2016.71.3495. Epub 2018 Jan 26.
7
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.与免疫检查点阻断相关的免疫相关不良事件。
N Engl J Med. 2018 Jan 11;378(2):158-168. doi: 10.1056/NEJMra1703481.
8
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.奥拉帕利治疗携种系 BRCA 突变的转移性乳腺癌患者。
N Engl J Med. 2017 Aug 10;377(6):523-533. doi: 10.1056/NEJMoa1706450. Epub 2017 Jun 4.
9
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.卡培他滨辅助治疗新辅助化疗后的乳腺癌。
N Engl J Med. 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645.
10
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.乳腺癌的病理完全缓解和长期临床获益:CTNeoBC 汇总分析。
Lancet. 2014 Jul 12;384(9938):164-72. doi: 10.1016/S0140-6736(13)62422-8. Epub 2014 Feb 14.