Zhang Jingjia, Zhang Dong, Du Juan, Zhou Yang, Cai Yunting, Sun Ruixue, Zhou Jiali, Tian Jingjing, Wu Honglong, Lu Minya, Xu Yingchun, Yang Qiwen
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China.
IDCases. 2021 Jan 23;23:e01055. doi: 10.1016/j.idcr.2021.e01055. eCollection 2021.
is an opportunistic pathogenic fungus commonly reported in southeast Asia. infection predominantly occurs in patients with immunodeficiency and can be fatal if diagnosis and treatment were delayed. Conventional diagnosis of infection relies heavily on tissue culture and histologic analysis, which is time consuming and has limited positive rate. Rapid and accurate diagnosis of remains urgent for effective therapy and prevention. This case is the first reported infection in non-HIV patients in north China diagnosed by mNGS. The successful diagnosis of infection assistant by mNGS underlies the potential of this technique in rapid etiological diagnosis.
是一种在东南亚地区常见的机会致病性真菌。感染主要发生在免疫缺陷患者中，如果诊断和治疗延迟可能会致命。传统的感染诊断严重依赖组织培养和组织学分析，这既耗时又阳性率有限。对于有效的治疗和预防而言，快速准确地诊断仍然十分迫切。该病例是中国北方首例通过宏基因组测序（mNGS）诊断的非HIV患者感染病例。mNGS辅助成功诊断感染病例凸显了该技术在快速病因诊断方面的潜力。
