School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Chem Soc Rev. 2021 Apr 7;50(7):4231-4244. doi: 10.1039/d0cs01075h. Epub 2021 Feb 18.
According to the World Health Organization (WHO), there were 18.1 million new cancer cases and 9.6 million cancer deaths reported worldwide in 2018. These numbers are expected to rise over the next decade, and the development of new and effective cancer treatments and diagnostic tools is urgently required, particularly for aggressive and intractable malignant cancers such as those of the brain. An exciting field of cancer research involves combining therapeutic and diagnostic tools into a single 'theranostic' platform. The role of theranostics in the personalized management of oncology patients is increasing, as is the demand for new types of theranostic agents. Some of the most promising cancer theranostics exploit the lanthanoid metal gadolinium, an element possessing favourable therapeutic and imaging properties.
根据世界卫生组织（WHO）的数据，2018 年全球报告有 1810 万例新癌症病例和 960 万例癌症死亡病例。预计在未来十年内，这些数字还会上升，因此迫切需要开发新的、有效的癌症治疗方法和诊断工具，特别是针对脑内等侵袭性和难治性恶性癌症。癌症研究的一个令人兴奋的领域是将治疗和诊断工具结合到一个单一的“治疗诊断学”平台中。治疗诊断学在肿瘤患者的个性化管理中的作用正在增加，对新型治疗诊断试剂的需求也在增加。一些最有前途的癌症治疗诊断学利用了镧系金属钆，钆是一种具有良好治疗和成像特性的元素。
