Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-S107-1, Atlanta, GA 30341. Email:
Prev Chronic Dis. 2021 Feb 18;18:E15. doi: 10.5888/pcd18.200242.
Little information is available about racial/ethnic and geographic variations in long-term survival among older patients (≥65) after acute ischemic stroke (AIS).
We examined data on 1,019,267 Medicare fee-for-service (FFS) beneficiaries aged 66 or older, hospitalized with a primary diagnosis of AIS from 2008 through 2012. Survival was defined as the time from the date of AIS to date of death, or an end of follow-up date of December 31, 2017. We used Cox proportional hazard models to estimate 5-year survival after AIS, adjusted for age, sex, race and Hispanic ethnicity, poverty level, Charlson Comorbidity Index, and state.
Among 1,019,267 Medicare FFS beneficiaries hospitalized with AIS from 2008 through 2012, we documented 701,718 deaths (68.8%) during a median of 4 years of follow-up with 4.08 million person-years. The overall adjusted 5-year survival was 44%. Non-Hispanic Black men had the lowest 5-year survival, and 5-year survival varied significantly by state, from the highest at 49.1% (North Dakota) to the lowest at 40.5% (Hawaii). The ranges between the highest and lowest 5-year survival rates across states also varied significantly by racial/ethnic groups, with percentage point differences of 9.6 among non-Hispanic White, 11.3 among non-Hispanic Black, 17.7 among Hispanic, and 28.5 among other racial/ethnic beneficiaries.
We identified significant racial/ethnic and geographic variations in 5-year survival rates after AIS among 2008-2012 Medicare FFS beneficiaries. Further study is needed to understand the reasons for these variations and develop prevention strategies to improve survival and racial disparities in survival after AIS.
关于年龄≥65 岁的老年急性缺血性脑卒中(AIS)患者长期生存的种族/民族和地域差异,相关信息有限。
我们分析了 2008 年至 2012 年期间,因 AIS 住院且主要诊断为 AIS 的 1,019,267 名 Medicare 收费服务(FFS)受益人的数据。生存定义为从 AIS 发病日期到死亡日期或 2017 年 12 月 31 日随访结束日期的时间。我们使用 Cox 比例风险模型,调整年龄、性别、种族和西班牙裔、贫困水平、Charlson 合并症指数和州等因素,估计 AIS 后 5 年的生存率。
在 2008 年至 2012 年期间因 AIS 住院的 1,019,267 名 Medicare FFS 受益人中,在中位 4 年的随访中,记录了 701,718 例死亡(68.8%),随访人数为 408 万人年。整体调整后的 5 年生存率为 44%。非西班牙裔黑人男性的 5 年生存率最低,且各州之间的 5 年生存率差异显著,从最高的 49.1%(北达科他州)到最低的 40.5%(夏威夷州)。各州之间的 5 年生存率差异也因种族/民族群体而显著不同,非西班牙裔白种人之间相差 9.6 个百分点,非西班牙裔黑种人之间相差 11.3 个百分点,西班牙裔之间相差 17.7 个百分点,其他种族/民族之间相差 28.5 个百分点。
我们发现,2008-2012 年 Medicare FFS 受益人中,AIS 后 5 年生存率存在显著的种族/民族和地域差异。需要进一步研究以了解这些差异的原因,并制定预防策略,以提高 AIS 后患者的生存率和减少生存差异。