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用于癌前病变计算机辅助诊断的宫颈组织病理学数据集。

A Cervical Histopathology Dataset for Computer Aided Diagnosis of Precancerous Lesions.

出版信息

IEEE Trans Med Imaging. 2021 Jun;40(6):1531-1541. doi: 10.1109/TMI.2021.3059699. Epub 2021 Jun 1.

Abstract

Cervical cancer, as one of the most frequently diagnosed cancers worldwide, is curable when detected early. Histopathology images play an important role in precision medicine of the cervical lesions. However, few computer aided algorithms have been explored on cervical histopathology images due to the lack of public datasets. In this article, we release a new cervical histopathology image dataset for automated precancerous diagnosis. Specifically, 100 slides from 71 patients are annotated by three independent pathologists. To show the difficulty of the task, benchmarks are obtained through both fully and weakly supervised learning. Extensive experiments based on typical classification and semantic segmentation networks are carried out to provide strong baselines. In particular, a strategy of assembling classification, segmentation, and pseudo-labeling is proposed to further improve the performance. The Dice coefficient reaches 0.7833, indicating the feasibility of computer aided diagnosis and the effectiveness of our weakly supervised ensemble algorithm. The dataset and evaluation codes are publicly available. To the best of our knowledge, it is the first public cervical histopathology dataset for automated precancerous segmentation. We believe that this work will attract researchers to explore novel algorithms on cervical automated diagnosis, thereby assisting doctors and patients clinically.

摘要

宫颈癌是全球最常见的癌症之一,早期发现时可治愈。组织病理学图像在宫颈病变的精准医学中起着重要作用。然而,由于缺乏公共数据集,很少有计算机辅助算法被探索用于宫颈组织病理学图像。在本文中,我们发布了一个新的用于自动化癌前诊断的宫颈组织病理学图像数据集。具体来说,有 71 名患者的 100 张切片由三位独立的病理学家进行了标注。为了展示任务的难度,我们通过完全监督学习和弱监督学习获得了基准。我们基于典型的分类和语义分割网络进行了广泛的实验,以提供强有力的基线。特别是,我们提出了一种组装分类、分割和伪标记的策略,以进一步提高性能。Dice 系数达到 0.7833,表明了计算机辅助诊断的可行性和我们的弱监督集成算法的有效性。该数据集和评估代码是公开的。据我们所知,这是第一个用于自动化癌前分割的公共宫颈组织病理学数据集。我们相信这项工作将吸引研究人员探索新的算法来辅助宫颈的自动诊断,从而为临床医生和患者提供帮助。

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