Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Institute of Respiratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Institute of Respiratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Sleep Med Rev. 2021 Aug;58:101444. doi: 10.1016/j.smrv.2021.101444. Epub 2021 Jan 29.
Chronic obstructive pulmonary disease (COPD) is a major health burden worldwide. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by worsening of patients' respiratory symptoms that requires a modification in medication. This event could accelerate disease progression and increase the risk of hospital admissions and mortality. Both insomnia and obstructive sleep apnea (OSA) are prevalent in patients with COPD, and are linked to increased susceptibility to AECOPD. Improper treatment of insomnia may increase the risk of adverse respiratory outcomes for patients with COPD, while effective continuous positive airway pressure (CPAP) treatment may reduce the risk of AECOPD and mortality in patients with overlap syndrome. Sleep disorders should be considered in clinical management for COPD.
慢性阻塞性肺疾病（COPD）是全球范围内的一个主要健康负担。慢性阻塞性肺疾病急性加重（AECOPD）的特征是患者的呼吸症状恶化，需要调整药物治疗。这一事件可能会加速疾病进展，增加住院和死亡的风险。失眠和阻塞性睡眠呼吸暂停（OSA）在 COPD 患者中都很常见，并且与 AECOPD 的易感性增加有关。失眠的治疗不当可能会增加 COPD 患者发生不良呼吸结局的风险，而有效的持续气道正压通气（CPAP）治疗可能会降低重叠综合征患者 AECOPD 和死亡率的风险。在 COPD 的临床管理中应考虑睡眠障碍。
