Yang Jie, Wang Lihua, Jia Renbing
Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
J Cancer. 2020 Jan 17;11(7):1761-1767. doi: 10.7150/jca.38598. eCollection 2020.
Despite extensive research in the cancer field, cancer remains one of the most prevalent diseases. There is an urgent need to identify specific targets that are safe and effective for the treatment of cancer. In recent years, cancer metabolism has come into the spotlight in cancer research. Lipid metabolism, especially cholesterol metabolism, plays a critical role in membrane synthesis as well as lipid signaling in cancer. This review focuses on the contribution of the cholesterol synthesis pathway to tumorigenesis, cancer progression and metastasis. In conclusion, cholesterol metabolism could be an effective target for novel anticancer treatment.
尽管在癌症领域进行了广泛的研究，但癌症仍然是最普遍的疾病之一。迫切需要确定对癌症治疗安全有效的特定靶点。近年来，癌症代谢在癌症研究中备受关注。脂质代谢，尤其是胆固醇代谢，在癌症的膜合成以及脂质信号传导中起着关键作用。本综述重点关注胆固醇合成途径对肿瘤发生、癌症进展和转移的作用。总之，胆固醇代谢可能是新型抗癌治疗的有效靶点。
