人乳腺癌中neu癌基因的扩增与过表达。
Amplification and over-expression of the neu oncogene in human breast carcinomas.
作者信息
van de Vijver M J, Mooi W J, Peterse J L, Nusse R
机构信息
Division of Molecular Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
出版信息
Eur J Surg Oncol. 1988 Apr;14(2):111-4.
PMID:3360152
Abstract
Amplification of the neu (or c-erbB-2 or HER) oncogene is found to be present in 15-30% of human breast carcinomas and has been reported to correlate with poor prognosis. We briefly review the literature on this subject with emphasis on our own results on immunohistochemical detection of neu overproduction in paraffin embedded tissue sections of human breast carcinomas.
摘要
在15%-30%的人类乳腺癌中发现存在neu（或c-erbB-2或HER）癌基因扩增，并且据报道这与预后不良相关。我们简要回顾关于该主题的文献，重点是我们自己在人乳腺癌石蜡包埋组织切片中对neu过表达进行免疫组织化学检测的结果。
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