c-erbB-2表达在子宫颈癌中的预后价值。
Prognostic value of c-erbB-2 expression in uterine cervical carcinoma.
作者信息
Hale R J, Buckley C H, Fox H, Williams J
机构信息
Department of Reproductive Pathology, St Mary's Hospital, Manchester.
出版信息
J Clin Pathol. 1992 Jul;45(7):594-6. doi: 10.1136/jcp.45.7.594.
AIMS
To study the pattern of expression and prognostic importance of c-erbB-2 protein in cervical carcinoma.
METHODS
Sixty two cases of stage IB/IIA cervical carcinoma, representing the three main tumour types, were investigated immunohistochemically for the presence of c-erbB-2 protein expression, using a monoclonal antibody (CB11) to its internal domain. Follow up of at least five years' duration was available in all cases.
RESULTS
Definite membrane staining was seen in 38.7% of cases. There was a strong correlation with poor survival (p less than 0.0001) particularly. For those with adenocarcinomas, this was the case when nodal metastases were present. In contrast, for squamous carcinomas and adenosquamous carcinomas, the association with a poor prognosis was most apparent in those patients without lymph node metastases.
CONCLUSIONS
These findings raise the possibility that immunostaining for c-erbB-2 protein could be used as a prognostic marker and may help identify those patients for whom early adjuvant treatment might be beneficial.
目的
研究c-erbB-2蛋白在宫颈癌中的表达模式及其预后意义。
方法
选取62例ⅠB/ⅡA期宫颈癌患者，代表三种主要肿瘤类型，采用针对c-erbB-2蛋白内部结构域的单克隆抗体（CB11）进行免疫组织化学检测，以确定c-erbB-2蛋白的表达情况。所有病例均有至少5年的随访资料。
结果
38.7%的病例可见明确的膜染色。其与较差的生存率密切相关（p<0.0001），特别是对于腺癌患者，有淋巴结转移时更是如此。相比之下，对于鳞癌和腺鳞癌患者，无淋巴结转移者与预后不良的关联最为明显。
结论
这些发现提示，c-erbB-2蛋白免疫染色有可能作为一种预后标志物，有助于识别那些可能从早期辅助治疗中获益的患者。
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