College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029, China.
Food Chem. 2021 May 30;345:128625. doi: 10.1016/j.foodchem.2020.128625. Epub 2020 Nov 16.
Small molecules in food contact materials may migrate into food during their contact. To extensively analyze the migrants, non-targeted screening is needed to detect the migrants. The migrants' detection is difficult because of the complexity and the trace amount of the migrants. In this work, the dissolution precipitation method was used to extract small molecules in Polyamide (PA) kitchenware. The extract solutions were screened by ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) for non-targeted analysis and 64 different small molecules in materials were identified through the screening of a self-built database. Then, migration tests were performed to analyze migrants in food simulants. It suggests that the abundance of PA oligomers was the highest in migrants. The risk assessment of migrants revealed that the exposure of most migrants was at a safer level unlike the exposure of PA oligomers that exceeded their threshold of toxicological concern (TTC).
食品接触材料中的小分子物质在接触食品时可能会迁移到食品中。为了广泛分析这些迁移物，需要进行非靶向筛选以检测迁移物。由于迁移物的复杂性和痕量性，其检测具有一定难度。在本工作中，采用溶解沉淀法提取聚酰胺（PA）厨具中的小分子物质。通过超高效液相色谱-四极杆飞行时间质谱法（UPLC-QTOF-MS）对提取液进行非靶向分析，并通过自建数据库筛选出 64 种不同的材料小分子。然后，进行迁移试验以分析食品模拟物中的迁移物。结果表明，在迁移物中，PA 低聚物的丰度最高。对迁移物的风险评估表明，与超过毒理学关注阈值（TTC）的 PA 低聚物暴露相比，大多数迁移物的暴露处于更安全的水平。
