Meyers S, Janowitz H D, Gumaste V V, Abramson R G, Berman L J, Venkataseshan V S, Dickman S H
Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York.
Gastroenterology. 1988 Jun;94(6):1503-7. doi: 10.1016/0016-5085(88)90692-0.
Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.
