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同时性双喉肿瘤:诊断和治疗的挑战。

Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge.

机构信息

Otolaryngology, Aberdeen Royal Infirmary, Aberdeen, UK

Oncology, Aberdeen Royal Infirmary, Aberdeen, UK.

出版信息

BMJ Case Rep. 2021 Feb 18;14(2):e239797. doi: 10.1136/bcr-2020-239797.

Abstract

Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx-a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.

摘要

平滑肌肉瘤是一种罕见发生于喉部的软组织肿瘤。本病例报告描述了一位 77 岁男性因声音嘶哑就诊耳鼻喉科的临床表现和诊治经过,经潘氏喉镜检查和活检后发现为巨大的会厌上部平滑肌肉瘤。患者随后接受了喉切除术治疗该肿瘤,但出乎意料的是,喉切除术标本的组织学分析显示喉部存在第二个原发性肿瘤——鳞状细胞癌(SCC)。患者进一步接受了颈部放疗。治疗 3 年后,两种肿瘤均无复发迹象。本病例报告讨论了喉部平滑肌肉瘤与 SCC 共存的极少数类似病例,并围绕该罕见表现的治疗方法整理了相关证据。

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本文引用的文献

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Radiological reasoning: submucosal laryngeal mass.放射学诊断思路:喉部黏膜下肿物
AJR Am J Roentgenol. 2008 Sep;191(3 Suppl):S18-21. doi: 10.2214/AJR.07.7047.
7
Simultaneous squamous cell carcinoma with leiomyosarcoma of the larynx.喉同时发生鳞状细胞癌和平滑肌肉瘤。
Auris Nasus Larynx. 2009 Apr;36(2):239-43. doi: 10.1016/j.anl.2008.05.012. Epub 2008 Jul 9.
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Leiomyosarcoma of the larynx. Case report.喉平滑肌肉瘤。病例报告。
Ann Otol Rhinol Laryngol. 1999 Aug;108(8):794-6. doi: 10.1177/000348949910800814.

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