Iqbal F R W, Sani A, Gendeh B S, Aireen I
Department of Otorhinolaryngology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Kuala Lumpur, Malaysia.
Med J Malaysia. 2008 Dec;63(5):417-8.
Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours. Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature. No cases, to our knowledge, have been reported in literature of a single patient with all three laryngeal, lung and thyroid malignancies. We report one such case of a 71-year-old Chinese man who had undergone a total laryngectomy for a recurrent cancer of the larynx only to be found to have tumours of the lung and thyroid in the post-operative period and he eventually died of post-operative complications. We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).
患有多种原发性恶性肿瘤的患者，通常根据其出现的时间顺序，被描述为同时性、同步性或异时性肿瘤。肺部恶性肿瘤与头颈部肿瘤同时出现的情况已有充分记载，而文献中也有少量关于甲状腺同步癌伴有喉部病变的报道。据我们所知，文献中尚未报道过同一患者同时患有喉、肺和甲状腺三种恶性肿瘤的病例。我们报告了这样一例病例，一名71岁的中国男性因复发性喉癌接受了全喉切除术，但在术后被发现患有肺部和甲状腺肿瘤，最终死于术后并发症。我们还讨论了头颈部鳞状细胞癌（SCC）患者中肺部和甲状腺恶性肿瘤的筛查。
