Zhang Xiaoli, Zhu Ying
Liver Disease Center of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Onco Targets Ther. 2021 Feb 10;14:917-927. doi: 10.2147/OTT.S289064. eCollection 2021.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies around the world. The self-renewal, proliferation, differentiation, and tumorigenic potential of liver cancer stem cells (LCSCs) may account for the high recurrence rate and the refractory feature of HCC. Despite extensive researches, the underlying regulatory mechanism of LCSCs has not been fully disclosed. Long nonprotein coding RNAs (lncRNAs) may exert an essential role in regulating various biological functions of LCSCs, such as maintaining the stemness of cancer stem cells (CSCs) and promoting tumor development. Therefore, it is highly critical to determine which lncRNAs can control LCSCs functions and understand how LCSCs are regulated by lncRNAs. Herein, we summarized lncRNAs and the main signaling pathways involved in the regulation of LCSCs found in recent years. Moreover, we shed light on the existence of the network system of lncRNAs and LCSCs, which may provide valuable clues on targeting LCSCs.
肝细胞癌（HCC）是全球最常见的恶性肿瘤之一。肝癌干细胞（LCSCs）的自我更新、增殖、分化和致瘤潜能可能是导致HCC高复发率和难治性的原因。尽管进行了广泛研究，但LCSCs的潜在调控机制尚未完全揭示。长链非蛋白质编码RNA（lncRNAs）可能在调节LCSCs的各种生物学功能中发挥重要作用，如维持癌症干细胞（CSCs）的干性和促进肿瘤发展。因此，确定哪些lncRNAs可以控制LCSCs的功能以及了解lncRNAs如何调控LCSCs至关重要。在此，我们总结了近年来发现的参与LCSCs调控的lncRNAs和主要信号通路。此外，我们还揭示了lncRNAs与LCSCs网络系统的存在，这可能为靶向LCSCs提供有价值的线索。
