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长链非编码RNA SLC16A1-AS1通过miR-194/SOCS2轴抑制宫颈鳞状细胞癌（CSCC）的细胞增殖。

LncRNA SLC16A1-AS1 Suppresses Cell Proliferation in Cervical Squamous Cell Carcinoma (CSCC) Through the miR-194/SOCS2 Axis.

作者信息

Zhang Huizhen, Jin Shuangling, Ji Aifang, Ma Ying, Zhang Chunyan, Wang Ailan, Wang Rui

机构信息

Department of Gynecology, Heping Hospital Affiliated to Changzhi Medical College, Changzi, Shanxi Province, 046000, People's Republic of China.

Department of Clinical Laboratory, Heping Hospital Affiliated to Changzhi Medical College, Changzi, Shanxi Province, 046000, People's Republic of China.

出版信息

Cancer Manag Res. 2021 Feb 11;13:1299-1306. doi: 10.2147/CMAR.S276629. eCollection 2021.

DOI:10.2147/CMAR.S276629
PMID:33603475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7884948/
Abstract

BACKGROUND

SLC16A1-AS1 has been characterized as an oncogenic long non-coding (lncRNA) in breast cancer and bladder cancer, while its role in cervical squamous cell carcinoma (CSCC) is unknown.

METHODS

CSCC and non-tumor tissue samples were collected from 60 female patients, and qPCR was performed to detect the expression of SLC16A1-AS1, miR-194 and SOCS2. Luciferase reporter assay was performed to detect the interaction between SLC16A1-AS1 and miR-194. Colony formation assay was used to detect cell proliferation.

RESULTS

SLC16A1-AS1 was down-regulated in CSCC and correlated with poor survival. Overexpression of SLC16A1-AS1 could inhibit the proliferation of cervical cancer cells. In addition, SLC16A1-AS1 could sponge miR-194 and increase the expression levels of SOCS2, ultimately inhibiting the proliferation of cervical cancer cells.

CONCLUSION

SLC16A1-AS1 was downregulated in CSCC and suppressed cell proliferation in cervical squamous cell carcinoma (CSCC) through the miR-194/SOCS2 axis.

摘要

背景

SLC16A1-AS1在乳腺癌和膀胱癌中已被表征为一种致癌性长链非编码RNA（lncRNA），而其在宫颈鳞状细胞癌（CSCC）中的作用尚不清楚。

方法

收集60例女性患者的CSCC和非肿瘤组织样本，进行qPCR检测SLC16A1-AS1、miR-194和SOCS2的表达。进行荧光素酶报告基因检测以检测SLC16A1-AS1与miR-194之间的相互作用。采用集落形成试验检测细胞增殖。

结果

SLC16A1-AS1在CSCC中表达下调，且与较差的生存率相关。SLC16A1-AS1的过表达可抑制宫颈癌细胞的增殖。此外，SLC16A1-AS1可吸附miR-194并增加SOCS2的表达水平，最终抑制宫颈癌细胞的增殖。

结论

SLC16A1-AS1在CSCC中表达下调，并通过miR-194/SOCS2轴抑制宫颈鳞状细胞癌（CSCC）的细胞增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/8cca09779e76/CMAR-13-1299-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/c160b1ab970c/CMAR-13-1299-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/eba813b9d0c1/CMAR-13-1299-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/b0685b6aadb6/CMAR-13-1299-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/84b4918ec60a/CMAR-13-1299-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/8cca09779e76/CMAR-13-1299-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/c160b1ab970c/CMAR-13-1299-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/eba813b9d0c1/CMAR-13-1299-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/b0685b6aadb6/CMAR-13-1299-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/84b4918ec60a/CMAR-13-1299-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4716/7884948/8cca09779e76/CMAR-13-1299-g0005.jpg

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