Bagher Amina M, Neamatallah Thikryat, Balto Ghadeer, Almikhy Lina, Almutairi Sara S, Abushal Mohammed O, Baghlaf Khlood, Bagher Sara M
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King AbdulAziz University, Jeddah, Saudi Arabia.
Department of Pediatric Dentistry, Faculty of Dentistry, King AbdulAziz University, Jeddah, Saudi Arabia.
Saudi Pharm J. 2021 Jan;29(1):53-58. doi: 10.1016/j.jsps.2020.12.006. Epub 2020 Dec 30.
Integrating pharmacogenetics (PGx) testing into clinical practice leads to personalized medicine, which improves treatments' efficacy and safety. Successful implementation of such a service requires sufficient knowledge, perception, and self-confidence among healthcare providers, especially pharmacists.
To evaluate governmental hospital pharmacists' knowledge, perception, and self-confidence toward PGx testing in Jeddah, Kingdom of Saudi Arabia.
This cross-sectional study was conducted using previously validated questionnaire. Pharmacists working in five randomly selected general governmental hospitals in Jeddah between August and October 2019 were interviewed. Comparative and descriptive analyses were used to analyze the data, and the significance level was at -value < 0.05.
A total of 119 pharmacists with a mean (±SD) age of 31.2 (±5.05) years were included with a response rate of 79.3%. The average total mean (±SD) score for PGx knowledge-based questions was low (2.4 ± 1.09 out of 5). Most of the participants, with a total mean score of (10.1 ± 1.6 out of 12), revealed a positive perception toward PGx testing and its implications. A moderate self-confidence score for utilizing PGx testing (4.3 ± 2.3 out of 8) was observed among the participants. Pharmacists who had completed postgraduate studies had a statistically higher mean knowledge score ( = 0.006) compared with pharmacists with undergraduate degrees.
Governmental hospital pharmacists have limited knowledge and understanding about PGx testing; however, the majority expressed a high level of awareness and agreed that PGx testing is a valuable tool for enhancing drug efficacy and safety. The study also highlighted the importance of improving pharmacists' knowledge about PGx testing, which will help them in implementing such a valuable service into their clinical practice in Saudi hospitals.
将药物遗传学（PGx）检测整合到临床实践中可实现个性化医疗，从而提高治疗的有效性和安全性。成功实施此类服务需要医疗保健提供者，尤其是药剂师具备足够的知识、认知和自信。
评估沙特阿拉伯王国吉达市政府医院药剂师对PGx检测的知识、认知和自信程度。
本横断面研究使用先前验证过的问卷进行。对2019年8月至10月期间在吉达市五家随机选取的政府综合医院工作的药剂师进行了访谈。采用比较分析和描述性分析对数据进行分析，显著性水平为P值<0.05。
共纳入119名药剂师，平均（±标准差）年龄为31.2（±5.05）岁，回复率为79.3%。基于PGx知识问题的平均总分（±标准差）较低（满分5分，得2.4±1.09分）。大多数参与者（满分12分，平均总分10.1±1.6分）对PGx检测及其影响表现出积极的认知。参与者对利用PGx检测的自信得分中等（满分8分，得4.3±2.3分）。与本科学历的药剂师相比，完成研究生学业的药剂师平均知识得分在统计学上更高（P = 0.006）。
政府医院药剂师对PGx检测的知识和理解有限；然而，大多数人表示认知水平较高，并认同PGx检测是提高药物疗效和安全性的宝贵工具。该研究还强调了提高药剂师对PGx检测知识的重要性，这将有助于他们在沙特医院的临床实践中实施这一有价值的服务。
