Zhao Ying, Zeng Yan, Zeng Dong, Wang Hesong, Zhou Mengjia, Sun Ning, Xin Jinge, Khalique Abdul, Rajput Danish Sharafat, Pan Kangcheng, Shu Gang, Jing Bo, Ni Xueqin
Animal Microecology Institute, College of Veterinary, Sichuan Agricultural University, Chengdu, China.
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Front Microbiol. 2021 Jan 14;11:604462. doi: 10.3389/fmicb.2020.604462. eCollection 2020.
Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis - the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host-microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host-microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics-miRNA-host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.
益生菌被广泛认为有助于维持肠道稳态，即宿主与肠道微生物之间动态且健康的相互作用。此外，作为域间通讯的关键分子，微小RNA（miRNA）也可介导宿主与微生物的相互作用。然而，尚未有关于miRNA与益生菌之间关联的全面描述和总结。在本综述中，我们讨论了益生菌和miRNA在宿主与微生物相互作用中的作用，并提出了益生菌与各种肠道疾病中miRNA改变的关联以及益生菌作用的潜在分子机制。此外，我们提供了益生菌-miRNA-宿主/肠道微生物群轴在寻找与肠道微生物群高度相关的疾病管理方法中的应用前景，这可能对未来的研究有益。
