Soleymanzadeh Fatemeh, Mahmoodi Minoo, Shahidi Siamak
Department of Biology, Faculty of Basic Science, Hamedan Islamic Azad University, Hamadan, Iran.
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
J Family Reprod Health. 2020 Jun;14(2):102-105. doi: 10.18502/jfrh.v14i2.4352.
Diabetes mellitus is recognized as one of the serious global health problems. There are evidences regarding the high prevalence of sexual dysfunction in diabetic patients. Experimental studies revealed a positive effect of Vitex agnus-castus (Vitex), on sexual function and behaviors. In this research, the effect of Vitex on sexual hormones in streptozotocin-(STZ) induced diabetic rats was investigated. A Thirty adult female Wistar rats were divided into five groups. 1-control group (non-diabetic), 2- diabetic group (received normal saline) and three induced diabetic groups treated with different doses (400, 200 and 100 mg/kg) of Vitex. Treatment groups received Vitex fruit extract by gavage for 7 days. The levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and estrogen in serum were measured. Levels of LH, FSH, estrogen and progesterone and average body weight was lower in diabetic group compared to control group (p <0.010). Animals received high dose of Vitex fruit extract (400mg/kg) had significantly higher levels of serum LH, FSH, estrogen and progesterone compared to diabetic group (p < 0.010). In animals receiving minimum dose (100mg/kg) of Vitex, no difference was observed compared to diabetic group (p > 0.010). It can be concluded that Vitex fruit extract probably has regulatory effect on diabetes-induced change in the levels of sex hormones in female rats. Vitex fruit extract can improve serum levels of sex hormones in an animal model of STZ-induced diabetes.
糖尿病被公认为是严重的全球健康问题之一。有证据表明糖尿病患者性功能障碍的患病率很高。实验研究显示，贞节树（Vitex agnus-castus）对性功能和行为有积极作用。在本研究中，研究了贞节树对链脲佐菌素（STZ）诱导的糖尿病大鼠性激素的影响。将30只成年雌性Wistar大鼠分为五组。1-对照组（非糖尿病组），2-糖尿病组（接受生理盐水）和三组用不同剂量（400、200和100mg/kg）贞节树治疗的诱导糖尿病组。治疗组通过灌胃给予贞节树果实提取物7天。测量血清中促黄体生成素（LH）、促卵泡生成素（FSH）、孕酮和雌激素的水平。与对照组相比，糖尿病组的LH、FSH、雌激素和孕酮水平以及平均体重较低（p<0.010）。接受高剂量贞节树果实提取物（400mg/kg）的动物与糖尿病组相比，血清LH、FSH、雌激素和孕酮水平显著更高（p<0.010）。在接受最低剂量（100mg/kg）贞节树的动物中，与糖尿病组相比未观察到差异（p>0.010）。可以得出结论，贞节树果实提取物可能对糖尿病引起的雌性大鼠性激素水平变化具有调节作用。贞节树果实提取物可改善STZ诱导糖尿病动物模型中的血清性激素水平。
