单独及联合使用“贞节树”提取物和补充镁对长骨骨折女性的成骨和血管生成因子及骨折愈合的影响
Effects of "vitex agnus castus" extract and magnesium supplementation, alone and in combination, on osteogenic and angiogenic factors and fracture healing in women with long bone fracture.
作者信息
Eftekhari Mohammad Hassan, Rostami Zahra Hassanzadeh, Emami Mohammad Jafar, Tabatabaee Hamid Reza
机构信息
Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Bone and Joint Research Center, Chamran Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
J Res Med Sci. 2014 Jan;19(1):1-7.
BACKGROUND
The purpose of this study was to investigate the effects of the combination of vitex agnus castus extract, as a source of phytoestrogens, plus magnesium supplementation on osteogenic and angiogenic factors and callus formation in women with long bone fracture.
MATERIAL AND METHODS
In a double-blind randomized placebo controlled trial, 64 women with long bone fracture, 20-45 years old, were randomly allocated to receive 1) one Agnugol tablet (4 mg dried fruit extract of vitex agnus castus) plus 250 mg magnesium oxide (VAC + Mg group (n = 10)), 2) one Agnugol tablet plus placebo (VAC group (n = 15)), 3) placebo plus 250 mg magnesium oxide (Mg group (n = 12)), or 4) placebo plus placebo (placebo group (n = 14)) per day for 8 weeks. At baseline and endpoint of the trial, serum alkaline phosphatase, osteocalcin, and vascular endothelial growth factor (VEGF) were measured together with radiological bone assessment.
RESULTS
There were no significant differences in the characteristic aspects of concern between the four groups at baseline. Despite the increased level of alkaline phosphatase in the VAC group (188.33 ± 16.27 to 240.40 ± 21.49, P = 0.05), administration of VAC + Mg could not increase alkaline phosphatase activity. However, treatment with VAC + Mg significantly enhanced the osteocalcin level. The serum concentration of VEGF was increased in the VAC group (269.04 ± 116.63 to 640.03 ± 240.16, P < 0.05). Callus formation in the VAC + Mg group was higher than the other groups but the differences between the four groups were not significant (P = 0.39). No relevant side effect was observed in patients in each group.
CONCLUSION
Our results suggest that administration of vitex agnus castus plus magnesium may promote fracture healing. However, more studies need to further explore the roles of vitex agnus castus in fracture repair processes.
背景
本研究旨在探讨作为植物雌激素来源的贞洁树提取物与补充镁联合使用，对长骨骨折女性的成骨和血管生成因子以及骨痂形成的影响。
材料与方法
在一项双盲随机安慰剂对照试验中，将64名年龄在20至45岁之间的长骨骨折女性随机分配，使其每天接受以下治疗，为期8周：1）一片Agnugol片（4毫克贞洁树干果提取物）加250毫克氧化镁（VAC + Mg组，n = 10）；2）一片Agnugol片加安慰剂（VAC组，n = 15）；3）安慰剂加250毫克氧化镁（Mg组，n = 12）；或4）安慰剂加安慰剂（安慰剂组，n = 14）。在试验的基线和终点，测量血清碱性磷酸酶、骨钙素和血管内皮生长因子（VEGF），并进行放射学骨评估。
结果
四组在基线时关注的特征方面无显著差异。尽管VAC组碱性磷酸酶水平有所升高（从188.33±16.27升至240.40±21.49，P = 0.05），但给予VAC + Mg并不能增加碱性磷酸酶活性。然而，VAC + Mg治疗显著提高了骨钙素水平。VAC组VEGF的血清浓度升高（从269.04±116.63升至640.03±240.16，P < 0.05）。VAC + Mg组的骨痂形成高于其他组，但四组之间的差异不显著（P = 0.39）。每组患者均未观察到相关副作用。
结论
我们的结果表明，给予贞洁树提取物加镁可能促进骨折愈合。然而，需要更多研究进一步探索贞洁树提取物在骨折修复过程中的作用。
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