Tomşa Anamaria Magdalena, Răchişan Andreea Liana, Aldea Andreea Alexandra, Ciumărnean Lorena
Department No. 9 Mother and Child, 2nd Clinic of Pediatrics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Internal Medicine IV, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Exp Ther Med. 2021 Mar;21(3):258. doi: 10.3892/etm.2021.9689. Epub 2021 Jan 25.
Nanoparticles (NPs) represent a major point of interest in the scientific field, with an increasing number of studies revealing promising results. Nano-oncology is a relatively new area of research that continues to expand, revealing new perspectives in both diagnosing and treating cancer. Treating pancreatic cancer (PC) remains a major challenge, with modest positive results, thus an increasing number of studies have focused on this disease. Out of all the NPs that have been used in experimental studies, gold NPs (GNPs) appear to be the most efficient, with little systemic toxicity. This review aims to summarize the latest studies that reveal the effects that GNPs have on PC cells, focusing on different ways in which they can be used to diagnose this disease, to induce apoptosis or cause cytotoxicity in cancer cells. Although literature has limited data concerning this specific topic, the results are promising. However more studies are required until GNPs can be used in clinical practice.
纳米颗粒（NPs）是科学领域的一个主要关注点，越来越多的研究显示出有前景的结果。纳米肿瘤学是一个相对较新的研究领域，并且仍在不断扩展，在癌症诊断和治疗方面都展现出新的视角。治疗胰腺癌（PC）仍然是一项重大挑战，取得的积极成果有限，因此越来越多的研究聚焦于这种疾病。在所有用于实验研究的纳米颗粒中，金纳米颗粒（GNPs）似乎是最有效的，且几乎没有全身毒性。这篇综述旨在总结最新的研究，这些研究揭示了金纳米颗粒对胰腺癌细胞的影响，重点关注它们可用于诊断这种疾病、诱导癌细胞凋亡或引起细胞毒性的不同方式。尽管关于这个特定主题的文献数据有限，但结果很有前景。然而，在金纳米颗粒能够用于临床实践之前，还需要更多的研究。
