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肾脏衰老过程与老年肾功能损害患者的管理(综述)

Kidney aging process and the management of the elderly patient with renal impairment (Review).

作者信息

Papacocea Raluca Ioana, Timofte Delia, Tanasescu Maria-Daniela, Balcangiu-Stroescu Andra-Elena, Balan Daniela Gabriela, Tulin Adrian, Stiru Ovidiu, Vacaroiu Ileana Adela, Mihai Andrada, Popa Cristian Constantin, Cosconel Cristina-Ileana, Enyedi Mihaly, Miricescu Daniela, Raducu Laura, Ionescu Dorin

机构信息

Discipline of Physiology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Dialysis, Emergency University Hospital, 050098 Bucharest, Romania.

出版信息

Exp Ther Med. 2021 Mar;21(3):266. doi: 10.3892/etm.2021.9697. Epub 2021 Jan 25.

Abstract

As life expectancy increases, a rise in the number of chronically ill patients is observed due to the aging population. Among the various diseases, chronic kidney disease is at present one of the main causes of morbidity and, due to its typical complications, it is also one of the most important causes of mortality in the general population. For these reasons, the understanding of the kidney aging process, its consequences and its adequate management are essential. The judicious use of certain types of drugs, the prevention of episodes of renal injury either by toxic mechanisms or by dehydration are important aspects and are part of the apropriate approach for elderly patients. The most effective treatment of various types of conditions with a negative impact on renal function and for which an increased incidence is known as we age should also be considered. Thus, in the case of elderly patients, in order to protect the kidneys, an integrative approach is recommended, one that includes both elements of prevention and the appropriate treatment of existing diseases.

摘要

随着预期寿命的增加,由于人口老龄化,慢性病患者数量出现上升。在各种疾病中,慢性肾脏病目前是发病的主要原因之一,并且由于其典型的并发症,它也是普通人群中最重要的死亡原因之一。基于这些原因,了解肾脏衰老过程、其后果及其适当管理至关重要。合理使用某些类型的药物,预防由毒性机制或脱水引起的肾损伤发作是重要方面,并且是老年患者适当治疗方法的一部分。还应考虑对肾功能有负面影响且随着年龄增长发病率增加的各种病症的最有效治疗方法。因此,对于老年患者,为了保护肾脏,建议采用综合方法,该方法包括预防措施和对现有疾病的适当治疗。

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本文引用的文献

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Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease.慢性肾脏病中的早期血管衰老与细胞衰老
Comput Struct Biotechnol J. 2019 Jun 18;17:721-729. doi: 10.1016/j.csbj.2019.06.015. eCollection 2019.
5
Plasma and urinary p21: potential biomarkers of AKI and renal aging.血浆和尿液中的 p21:急性肾损伤和肾脏老化的潜在生物标志物。
Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1329-F1335. doi: 10.1152/ajprenal.00328.2018. Epub 2018 Aug 1.
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Oxidative stress, aging, and diseases.氧化应激、衰老和疾病。
Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. eCollection 2018.
9
Structural and Functional Changes in Human Kidneys with Healthy Aging.健康衰老过程中人类肾脏的结构和功能变化
J Am Soc Nephrol. 2017 Oct;28(10):2838-2844. doi: 10.1681/ASN.2017040421. Epub 2017 Aug 8.
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