Dawczynski Christine
Junior Research Group Nutritional Concepts, Institute of Nutritional Science, Friedrich Schiller University Jena, Jena, Germany.
Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Leipzig, Germany.
Front Nutr. 2021 Feb 2;7:608854. doi: 10.3389/fnut.2020.608854. eCollection 2020.
Currently, there is a continuing upward trend for plant-based lifestyles in Germany and Europe. The implementation of vegetarian and vegan lifestyles is characterized by omitting defined food groups such as fish, meat, sausage (vegetarians), or dairy products and honey (vegans). This carries the risk of an undersupply of valuable nutrients. The NuEva study is designed to examine this hypothesis and to evaluate the impact of plant-based diets on health status and disease risk. The NuEva study is a parallel-designed trial with at least 55 participants for each diet (vegetarian, vegan, flexitarian [rare meat/sausage consumption, once or twice per week]), and participants who consume a traditional Western diet as the control group. In the screening period critical nutrients are identified for the studied diets by analysis of a broad spectrum of nutrients in the human samples (fatty acids, vitamins, minerals, trace elements, nutrient metabolites). Based on the data from the screening period, defined menu plans, ensuring an adequate nutrient intake in accordance with the nutritional guidelines are prepared for each group. The plans are adapted and personalized to individual energy requirements based on the basal metabolic rate and physical activity level. The compliance with the NuEva concept and their impact on nutrient status and cardiovascular risk factors are validated during the intervention period of the NuEva study over 1 year. To investigate the impact of the studied diets on the microbiome, feces samples are collected at the beginning and after the 12 months intervention period (follow up: 12 months). The NuEva study is designed to investigate the impact of common diets on health and disease status, with focus on prevention of cardiovascular diseases. In addition, the effectiveness of the prepared nutritional coaching strategy, ensuring optimal nutrient intake in accordance with the guidelines, is validated during the intervention period of the NuEva study. Registered under ClinicalTrials.gov Identifier no. NCT03582020.
目前，在德国和欧洲，以植物为基础的生活方式呈持续上升趋势。素食和纯素生活方式的实施特点是不吃特定的食物类别，如鱼类、肉类、香肠（素食者）或乳制品和蜂蜜（纯素食者）。这带来了宝贵营养物质供应不足的风险。NuEva研究旨在检验这一假设，并评估植物性饮食对健康状况和疾病风险的影响。NuEva研究是一项平行设计的试验，每种饮食（素食、纯素、弹性素食[每周食用一两次少量肉类/香肠]）至少有55名参与者，以食用传统西方饮食的参与者作为对照组。在筛查期，通过分析人体样本中的多种营养素（脂肪酸、维生素、矿物质、微量元素、营养代谢物）来确定所研究饮食的关键营养素。根据筛查期的数据，为每个组制定明确的菜单计划，确保按照营养指南摄入足够营养。这些计划根据基础代谢率和身体活动水平，针对个人能量需求进行调整和个性化定制。在NuEva研究为期1年的干预期内，验证对NuEva概念的依从性及其对营养状况和心血管危险因素 的影响。为了研究所研究饮食对微生物群 的影响，在干预期开始时和12个月后（随访：12个月）收集粪便样本。NuEva研究旨在调查常见饮食对健康和疾病状况的影响，重点是预防心血管疾病。此外，在NuEva研究的干预期内，验证所制定的营养指导策略的有效性，确保按照指南摄入最佳营养。在ClinicalTrials.gov注册，标识符为NCT03582020。
