Stemerowicz R, Möller B, Lobeck H, Oertel J, Hopf U
Klinikum Charlottenburg der Freien, Universität Berlin, Medizinische Klinik und Poliklinik.
Immun Infekt. 1988 Feb;16(1):12-5.
We report about a 40-year-old male patient suffering from a recurrent vasculitis with purpura since the age of 18. In 1983, a HBsAg-positive chronic active hepatitis with circulating immune complexes which contained HBsAg, immunoglobulin M and G as well as complement (C) was diagnosed. Serum and liver tissue were negative for HBcAg, HBeAg and hepatitis B virus (HBV) DNA; there was no evidence for HBV replication. HBsAg, IgM and C3 were demonstrable in the arteriolar walls of the skin. The results support the concept that complement activating immune complexes containing HBsAg and IgM anti HBs play a role in the pathogenesis of vasculitis as described here.
我们报告了一名40岁男性患者，自18岁起患有复发性血管炎并伴有紫癜。1983年，诊断出一名HBsAg阳性的慢性活动性肝炎患者，其循环免疫复合物中含有HBsAg、免疫球蛋白M和G以及补体（C）。血清和肝组织的HBcAg、HBeAg和乙型肝炎病毒（HBV）DNA均为阴性；没有HBV复制的证据。在皮肤的小动脉壁中可检测到HBsAg、IgM和C3。这些结果支持了这样一种概念，即含有HBsAg和抗HBs IgM的补体激活免疫复合物在本文所述的血管炎发病机制中起作用。
