School of Medicine and Surgery, University of Milano-Bicocca, building U8, room 2043 - via Cadore 48, 20900, Monza, MB, Italy.
Neurology Unit, San Gerardo Hospital, Monza, Italy.
Aging Clin Exp Res. 2021 Oct;33(10):2747-2751. doi: 10.1007/s40520-021-01806-1. Epub 2021 Feb 18.
To assess the prevalence of delirium (DEL) among older patients living at home and periodically visited by their General Practitioners (GPs).
Observational study.
In Italy, programmed home visits by the GPs are regularly scheduled for their vulnerable and frail patients who are often on poly-drug regimens and suffering from dementia.
N = 102 patients among those receiving programmed home visits by n = 6 GP based in the Brianza area (Lombardy).
Patients were screened for delirium with the Italian version of the 4AT, with a score ≥ 4 considered as a positive indicator for DEL. The Charlson Comorbidity Index (CCI), the Short Physical Performance Battery (SPPB), the presence of dementia, and benzodiazepine (BZD) use were recorded.
DEL+ was detected in almost half of the recruited sample (44.1%), and it was clearly associated with increased comorbidity and decreased motor abilities. Pre-existing dementia was documented in most of DEL+ patients (71.1%), while this was the case for only a minority of DEL- (5.2%, p < 0.00001). Analogously, BZD use was over-represented in the DEL+ group with respect to the DEL- one (73.3% vs. 22.8%, p < 0.00001).
DEL prevalence as detected by GP during programmed home visits is surprisingly high, and related to motor impairment, comorbidities (among which dementia), and BZD use. DEL prompt recognition should be one of the goals of GP-programmed home visits, since this treatable and preventable condition is associated to an elevated burden of frailty and risk of death.
评估定期接受全科医生(GP)上门访视的居家老年患者发生谵妄(DEL)的患病率。
观察性研究。
在意大利,GP 定期为脆弱和虚弱的患者安排上门访视,这些患者通常服用多种药物且患有痴呆症。
伦巴第大区 Brianza 地区的 6 名 GP 上门访视的患者中,有 102 名患者纳入本研究。
采用意大利版的 4AT 对患者进行 DEL 筛查,评分≥4 被认为是 DEL 的阳性指标。记录 Charlson 合并症指数(CCI)、简短体能状况量表(SPPB)、痴呆和苯二氮䓬类药物(BZD)的使用情况。
在招募的样本中,近一半(44.1%)患者被检出 DEL+,并且 DEL+与合并症增加和运动能力下降明显相关。在 DEL+患者中,大多数(71.1%)患者有预先存在的痴呆,而在 DEL-患者中,这一比例仅为少数(5.2%,p<0.00001)。类似地,DEL+组中 BZD 的使用明显多于 DEL-组(73.3% vs. 22.8%,p<0.00001)。
GP 在计划的上门访视中检测到的 DEL 患病率高得惊人,且与运动障碍、合并症(包括痴呆)和 BZD 的使用有关。GP 计划上门访视的目标之一应是及时识别 DEL,因为这种可治疗和可预防的疾病与衰弱和死亡风险增加有关。