Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Kolding Hospital, Kolding, Denmark; The Neuroepidemiology Research Group, Stockholm, Sweden.
Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Mult Scler. 2021 Oct;27(11):1799-1802. doi: 10.1177/1352458521996601. Epub 2021 Feb 19.
Depression is common in multiple sclerosis (MS); however, the underlying mechanism for the relationship remains unknown. In this study, we examined a putative causal relationship between depression and MS using a bidirectional Mendelian randomisation (MR) framework. Using the latest genome-wide association study data available, 168 non-major histocompatibility complex (MHC) independent variants associated with MS and 96 independent genetic variants associated with depression susceptibility were used. Maximum likelihood, weighted median, inverse variance weighted method and MR-Egger regression analyses were performed. There was no significant risk for the development of MS in persons carrying variants associated with depression or for risk of depression in individuals who are genetically susceptible to MS.
抑郁症在多发性硬化症（MS）中很常见；然而，其相关关系的潜在机制尚不清楚。在这项研究中，我们使用双向孟德尔随机化（MR）框架来研究抑郁症和 MS 之间的潜在因果关系。使用最新的全基因组关联研究数据，我们选择了 168 个与 MS 无关的非主要组织相容性复合体（MHC）独立变异，以及 96 个与抑郁易感性相关的独立遗传变异。进行了最大似然法、加权中位数法、逆方差加权法和 MR-Egger 回归分析。携带与抑郁相关的变异的个体患 MS 的风险或遗传上易患 MS 的个体患抑郁的风险没有显著增加。
