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补体途径在人类免疫缺陷病毒感染者中被激活，并与非艾滋病合并症相关。

The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities.

机构信息

Metaorganism Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.

出版信息

J Infect Dis. 2021 Oct 28;224(8):1405-1409. doi: 10.1093/infdis/jiab096.

DOI:10.1093/infdis/jiab096
PMID:33606018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8682793/
Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

摘要

在一项针对接受人类免疫缺陷病毒 (HIV) 治疗的个体的配对病例对照研究中进行的无偏血浆蛋白质组学分析显示，补体级联反应是 PWH 中富集程度最高的途径之一。特定的补体成分，即 C5，与非艾滋病合并症的患病率显著相关，其相关性强于先前建立的预测生物标志物。

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J Am Coll Cardiol. 2020 Apr 28;75(16):1926-1941. doi: 10.1016/j.jacc.2020.02.058.
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Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of sepsis.在狒狒脓毒症模型中，抑制补体C5可预防器官衰竭并降低死亡率。
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