Langlois D, Hoffstetter S, Malissard L, Pernot M, Taghian A
Department of Brachytherapy, Centre Alexis Vautrin, Vandoeuvre les Nancy, France.
Int J Radiat Oncol Biol Phys. 1988 May;14(5):849-53. doi: 10.1016/0360-3016(88)90004-1.
Between 1972 and 1984, 123 patients were treated using 192 Iridium afterloading techniques for recurrence or new cancer of the tongue or oropharynx arising in previously irradiated tissues. The actuarial local control was 67% at 2 years and 59% at 5 years. Local control of the tumor was achieved in the majority of these patients, the actuarial survival was only 48% at 2 years and 24% at 5 years. Twenty-eight patients developed mucosal necrosis. We analyzed prognostic factors for survival, local control, and complication. We proposed a selection for this salvage therapy.
1972年至1984年间，123例患者采用铱-192后装技术治疗先前接受过放疗的舌部或口咽复发癌或新发癌。2年时的精算局部控制率为67%，5年时为59%。这些患者中的大多数实现了肿瘤局部控制，但2年时的精算生存率仅为48%，5年时为24%。28例患者发生了黏膜坏死。我们分析了生存、局部控制和并发症的预后因素。我们提出了这种挽救性治疗的选择标准。
