Mazeron J J, Langlois D, Glaubiger D, Huart J, Martin M, Raynal M, Calitchi E, Ganem G, Faraldi M, Feuilhade F
Int J Radiat Oncol Biol Phys. 1987 Jul;13(7):957-62. doi: 10.1016/0360-3016(87)90031-9.
Between May 1971 and November 1980, 70 patients with recurrent or new oropharyngeal cancers arising in previously irradiated tissues were treated using iridium 192 afterloading techniques. The actuarial local control was 72% at 2 years and 69% at 5 years. Although local control of the tumor was achieved in the majority of these patients, only 10 patients remained alive at 5 years (14%). Patients with lesions of the faucial arch and posterior pharyngeal wall had the best results; local control was achieved in 100% of these patients. Patients with lesions of the base of tongue and of the glosso-tonsillar sulcus had poorer results; local control was achieved in 61%. Because these results compare favorably with the results of previously published series, we recommend re-irradiation with brachytherapy for recurrent or new malignancies arising in a previously irradiated oropharynx. When the lesion is located in the faucial arch, brachytherapy is the treatment of choice. When the lesion is located in the base of tongue, brachytherapy is a reasonable option.
1971年5月至1980年11月期间，70例复发性、新发或原发于既往接受过放疗组织的口咽癌患者接受了铱192后装技术治疗。2年时的精算局部控制率为72%，5年时为69%。尽管大多数患者实现了肿瘤的局部控制，但5年时仅10例患者存活（14%）。咽弓和咽后壁病变患者的效果最佳，这些患者中有100%实现了局部控制。舌根和舌扁桃体沟病变患者的效果较差，局部控制率为61%。由于这些结果与先前发表的系列研究结果相比具有优势，我们建议对既往接受过放疗的口咽部位出现的复发性或新发恶性肿瘤进行近距离放疗再程照射。当病变位于咽弓时，近距离放疗是首选治疗方法。当病变位于舌根时，近距离放疗是一个合理的选择。
