Division of Human Environmental Science, Mount Fuji Research Institute, Fuji-yoshida City, Yamanashi, Japan.
Department of Exercise and Sports Science, University of North Carolina, Chapel Hill, NC, USA.
Vasc Med. 2021 Aug;26(4):386-393. doi: 10.1177/1358863X20988899. Epub 2021 Feb 19.
Exposure to prolonged sitting increases blood pooling and the risk of lower-extremity vascular arterial and venous complications, including deep vein thrombosis. Compression garment stockings (CGS) may prevent pooling, thereby mitigating the associated vascular complications. Three aims were addressed: (i) does use of CGS help to prevent blood pooling; (ii) does blood pooling correlate with decreased stroke volume; and (iii) does use of CGS preserve leg arterial flow-mediated dilation and reactive hyperemia response. Twenty inactive participants (22 ± 4 years, 30% female, 22.1 ± 2.0 kg/m) were randomized to sit for 3 hours with (CGS) and without use of CGS. Blood pooling was determined using medial gastrocnemius total hemoglobin. Stroke volume was estimated using finger photoplethysmography, respectively. Macrovascular and microvascular function were measured using popliteal artery flow-mediated dilation and reactive hyperemia, respectively. In response to 3 hours of sitting: (i) there was an interaction effect for total hemoglobin ( < 0.001); the condition without use of CGS increased 10.5% (95% CI: 6.7 to 14.3) and CGS increased 4.3% (95% CI: 0.1 to 7.7); (ii) blood pooling was negatively associated with stroke volume ( = -0.58, 95% CI: -0.68 to -0.45); (iii) reactive hyperemia and flow-mediated arterial dilation was impaired after prolonged sitting, and use of CGS was not associated with attenuation of this impairment. Use of CGS decreases blood pooling but does not preserve arterial macrovascular and microvascular responses to prolonged sitting. Further study is warranted to determine whether CGS has additive benefits when combined with sitting interruption strategies.
长时间坐着会增加血液淤积和下肢动静脉并发症的风险，包括深静脉血栓形成。压缩服装袜（CGS）可以防止淤积，从而减轻相关的血管并发症。本研究有三个目的：（i）CGS 的使用是否有助于防止血液淤积；（ii）血液淤积是否与心输出量减少相关；（iii）CGS 的使用是否保持腿部动脉血流介导的扩张和反应性充血反应。20 名不活跃的参与者（22 ± 4 岁，30%为女性，22.1 ± 2.0 kg/m）被随机分为两组，分别在使用 CGS 和不使用 CGS 的情况下坐 3 小时。使用内侧腓肠肌总血红蛋白来确定血液淤积情况。使用指端光体积描记法分别估计心输出量。使用腘动脉血流介导的扩张和反应性充血来测量大血管和微血管功能。在 3 小时的坐姿期间：（i）总血红蛋白存在交互作用效应（<0.001）；不使用 CGS 的条件增加了 10.5%（95%CI：6.7 至 14.3），CGS 增加了 4.3%（95%CI：0.1 至 7.7）；（ii）血液淤积与心输出量呈负相关（= -0.58，95%CI：-0.68 至-0.45）；（iii）长时间坐着后反应性充血和血流介导的动脉扩张受损，而使用 CGS 与这种损伤的减弱无关。使用 CGS 可减少血液淤积，但不能维持动脉大血管和微血管对长时间坐着的反应。需要进一步研究以确定 CGS 与坐姿中断策略结合使用是否具有附加益处。
