Zenebe Chernet Baye, Chanie Wagaye Fentahun, Aregawi Aster Berhe, Andargie Tamiru Minwuye, Mihret Muhabaw Shumye
Gynecology and Obstetrics Department, University of Gondar, Gondar, Ethiopia.
United Nations Population Fund Supported Maternal Health Project, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Reprod Health. 2021 Feb 19;18(1):45. doi: 10.1186/s12978-021-01104-z.
Pelvic organ prolapse remains the public health challenge globally. Existing evidences report the effect of woman's weight on the pelvic organ prolapse inconsistently and this urges the need of pooled body weight effect on the pelvic organ prolapse. Although there was a previous work on this regard, it included papers reported before June 18/2015. Thus, updated and comprehensive evidence in this aspect is essential to devise strategies for interventions.
This review aimed at synthesizing evidence regarding the pooled effect of body weight on the pelvic organ prolapsed.
For this review, we searched all available articles through databases including PubMed, Web of Sciences, CINAHL, JBI library, Cochran library, PsycInfo and EMBASE as well as grey literature including Mednar, worldwide science, PschEXTRA and Google scholar. We included cohort, case-control, cross-sectional and experimental studies which had been reported between March 30, 2005 to March 30, 2020. In the effect analysis, we utilized random model. The heterogeneity of the studies was determined by I2 statistic and the publication bias was checked by Egger's regression test. Searching was limited to studies reported in the English language.
A total of 14 articles with 53,797 study participants were included in this systematic review (SR) and meta analysis (MA). The pooled result of this Meta analyses depict that body mass index (BMI) doesn't have statistical significant association with pelvic organ prolapse.
This review point out that women's body mass index has no significant effect on the development of pelvic organ prolapse. However, the readers should interpret the result with cautions due to the presence of considerable limitations in this work. Trial registration The protocol of this systematic review (SR) and meta analysis (MA) has been registered in PROSPERO databases with the Registration number of CRD42020186951.
盆腔器官脱垂仍是全球面临的公共卫生挑战。现有证据关于女性体重对盆腔器官脱垂的影响报道不一致，这促使人们需要汇总体重对盆腔器官脱垂的影响。尽管此前有关于这方面的研究，但其中包含的论文报道时间截至2015年6月18日。因此，这方面最新且全面的证据对于制定干预策略至关重要。
本综述旨在综合体重对盆腔器官脱垂汇总影响的证据。
对于本综述，我们通过包括PubMed、科学网、CINAHL、JBI图书馆、Cochran图书馆、PsycInfo和EMBASE等数据库以及包括Mednar、世界科学、PschEXTRA和谷歌学术在内的灰色文献搜索所有可用文章。我们纳入了2005年3月30日至2020年3月30日期间报道的队列研究、病例对照研究、横断面研究和实验研究。在效应分析中，我们采用随机模型。研究的异质性通过I²统计量确定，发表偏倚通过Egger回归检验检查。搜索仅限于英文报道的研究。
本系统评价（SR）和荟萃分析（MA）共纳入14篇文章，涉及53797名研究参与者。该荟萃分析的汇总结果表明，体重指数（BMI）与盆腔器官脱垂无统计学显著关联。
本综述指出，女性体重指数对盆腔器官脱垂的发生无显著影响。然而，由于本研究存在相当多的局限性，读者应谨慎解读结果。试验注册 本系统评价（SR）和荟萃分析（MA）的方案已在PROSPERO数据库注册，注册号为CRD42020186951。
