Rivero D P, Fox J, Skipor A K, Urban R M, Galante J O
Department of Orthopedic Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
J Biomed Mater Res. 1988 Mar;22(3):191-201. doi: 10.1002/jbm.820220304.
Porous titanium fiber implants for cementless skeletal fixation by bone ingrowth were treated with a calcium phosphate coating applied by a plasma flame-spray technique. In a paired experiment, treated and control implants were inserted in the humeri and olecranons of 36 adult dogs for periods of 1, 2, 4, and 6 weeks. After the animals were sacrificed, a biomechanical evaluation of the strength of skeletal fixation of the implants and a histologic evaluation of bone ingrowth was done. The mean shear strength of skeletal fixation at four weeks for the calcium phosphate-coated implants was 24% greater (P less than .01) than for paired controls. No difference in strength of fixation between treated and control implants was present at other time periods. The osteoconductive properties of the ceramic coating were demonstrated by bone forming in direct contact with the calcium phosphate coating on the metal fibers of the treated implants. No significant increase for the volume of bone ingrowth was established for treated implants compared to paired controls at any time period.
通过骨长入实现非骨水泥骨骼固定的多孔钛纤维植入物，采用等离子火焰喷涂技术施加磷酸钙涂层进行处理。在一项配对实验中，将经过处理的植入物和对照植入物分别植入36只成年犬的肱骨和尺骨鹰嘴，植入时间分别为1周、2周、4周和6周。处死动物后，对植入物的骨骼固定强度进行生物力学评估，并对骨长入情况进行组织学评估。磷酸钙涂层植入物在四周时的骨骼固定平均剪切强度比配对对照植入物高24%（P小于0.01）。在其他时间段，处理过的植入物和对照植入物之间的固定强度没有差异。通过与处理过的植入物金属纤维上的磷酸钙涂层直接接触形成骨组织，证明了陶瓷涂层的骨传导特性。在任何时间段，与配对对照相比，处理过的植入物的骨长入体积均未显著增加。
