Ducheyne P, Hench L L, Kagan A, Martens M, Bursens A, Mulier J C
J Biomed Mater Res. 1980 May;14(3):225-37. doi: 10.1002/jbm.820140305.
Skeletal fixation of permanent implants by new methods such as fixation by mechanical interlocking of bone with porous prosthetic coatings or chemical bonding with bioactive materials shows growing potential. This paper reports on the resulting skeletal fixation of a combined porous and bioactive material. Metal plugs with a porous metal fiber coating impregnated with hydroxyapatite were implanted for 2, 4, and 12 weeks and were compared to the parent porous, nonbioactive, metal fiber material. Statistical analysis of the interfacial failure shear stress, as obtained by mechanical testing, shows there is a marked influence of hydroxyapatite impregnation on the rate of bone ingrowth and the strength of the interfacial bond the few weeks following surgery. Microscopical examination reveals that the apparent stimulation of bone ingrowth into the surface pores of the implant is the reason for the increased rate of bond formation. The results are of particular clinical interest: with an increased rate of bone ingrowth, weight bearing might be allowed much earlier, thus reducing the recuperation period.
通过诸如骨与多孔假体涂层的机械互锁固定或与生物活性材料的化学键合等新方法对永久性植入物进行骨骼固定显示出越来越大的潜力。本文报道了一种多孔和生物活性材料组合所产生的骨骼固定情况。将浸渍有羟基磷灰石的多孔金属纤维涂层的金属栓植入2周、4周和12周，并与母体多孔、无生物活性的金属纤维材料进行比较。通过力学测试获得的界面失效剪切应力的统计分析表明，在手术后的几周内，羟基磷灰石浸渍对骨长入速率和界面结合强度有显著影响。显微镜检查显示，植入物表面孔隙中骨长入的明显刺激是键形成速率增加的原因。这些结果具有特殊的临床意义：随着骨长入速率的增加，可以更早地允许负重，从而缩短康复期。
