Department of Molecular and Cellular Biology, Department of Organismic and Evolutionary Biology, Center for Brain Science, Museum of Comparative Zoology, Harvard University and the Howard Hughes Medical Institute, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Neuron. 2021 Apr 7;109(7):1084-1099. doi: 10.1016/j.neuron.2021.02.002. Epub 2021 Feb 19.
Neuroscientists have long studied species with convenient biological features to discover how behavior emerges from conserved molecular, neural, and circuit level processes. With the advent of new tools, from viral vectors and gene editing to automated behavioral analyses, there has been a recent wave of interest in developing new, "nontraditional" model species. Here, we advocate for a complementary approach to model species development, that is, model clade development, as a way to integrate an evolutionary comparative approach with neurobiological and behavioral experiments. Capitalizing on natural behavioral variation in and investing in experimental tools for model clades will be a valuable strategy for the next generation of neuroscience discovery.
神经科学家长期以来一直在研究具有方便生物学特征的物种,以发现行为如何从保守的分子、神经和电路水平过程中出现。随着新工具的出现,从病毒载体和基因编辑到自动化行为分析,人们对开发新的“非传统”模式物种产生了浓厚的兴趣。在这里,我们提倡一种补充的模型物种发展方法,即模型进化枝发展,将进化比较方法与神经生物学和行为实验相结合。利用模型进化枝的自然行为变异并为其投资实验工具将是下一代神经科学发现的一项宝贵策略。